Reaction Details Report a problem with these data
Target
Serine/threonine-protein kinase 33
Ligand
BDBM65442
Substrate
n/a
Meas. Tech.
Luminescence Cell-Free Homogenous Dose Retest to Identify Inhibitors of Serine/Threonine Kinase 33 Activity
EC50
8490±n/a nM
Citation
 PubChem, PC Luminescence Cell-Free Homogenous Dose Retest to Identify Inhibitors of Serine/Threonine Kinase 33 Activity PubChem Bioassay (2010)[AID] 
Target
Name:
Serine/threonine-protein kinase 33
Synonyms:
STK33 | STK33_HUMAN | Serine/threonine-protein kinase 33
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57833.21
Organism:
Homo sapiens (Human)
Description:
gi_23943882
Residue:
514
Sequence:
MADSGLDKKSTKCPDCSSASQKDVLCVCSSKTRVPPVLVVEMSQTSSIGSAESLISLERKKEKNINRDITSRKDLPSRTSNVERKASQQQWGRGNFTEGKVPHIRIENGAAIEEIYTFGRILGKGSFGIVIEATDKETETKWAIKKVNKEKAGSSAVKLLEREVNILKSVKHEHIIHLEQVFETPKKMYLVMELCEDGELKEILDRKGHFSENETRWIIQSLASAIAYLHNNDIVHRDLKLENIMVKSSLIDDNNEINLNIKVTDFGLAVKKQSRSEAMLQATCGTPIYMAPEVISAHDYSQQCDIWSIGVVMYMLLRGEPPFLASSEEKLFELIRKGELHFENAVWNSISDCAKSVLKQLMKVDPAHRITAKELLDNQWLTGNKLSSVRPTNVLEMMKEWKNNPESVEENTTEEKNKPSTEEKLKSYQPWGNVPDANYTSDEEEEKQSTAYEKQFPATSKDNFDMCSSSFTSSKLLPAEIKGEMEKTPVTPSQGTATKYPAKSGALSRTKKKL
  
Inhibitor
Name:
BDBM65442
Synonyms:
2-(1,3-Dihydro-benzoimidazol-2-ylidene)-3-furan-2-yl-3-oxo-propionitrile | 2-(1,3-dihydrobenzimidazol-2-ylidene)-3-(2-furanyl)-3-oxopropanenitrile | 2-(1,3-dihydrobenzimidazol-2-ylidene)-3-(2-furyl)-3-keto-propionitrile | 2-(1,3-dihydrobenzimidazol-2-ylidene)-3-(furan-2-yl)-3-oxidanylidene-propanenitrile | 2-(1,3-dihydrobenzimidazol-2-ylidene)-3-(furan-2-yl)-3-oxopropanenitrile | MLS000723611 | SMR000305206 | cid_5347397
Type:
Small organic molecule
Emp. Form.:
C14H9N3O2
Mol. Mass.:
251.2402
SMILES:
O=C(C(C#N)c1nc2ccccc2[nH]1)c1ccco1
Structure:
Search PDB for entries with ligand similarity: