Reaction Details Report a problem with these data
Target
DNA damage-inducible transcript 3 protein
Ligand
BDBM30762
Substrate
n/a
Meas. Tech.
Dose-response primary assay and counterscreen assay for HTS small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress
IC50
1820±n/a nM
Citation
 PubChem, PC Dose-response primary assay and counterscreen assay for HTS small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress PubChem Bioassay (2010)[AID] 
Target
Name:
DNA damage-inducible transcript 3 protein
Synonyms:
Chop | Chop10 | DDIT3_MOUSE | Ddit3 | Gadd153
Type:
Enzyme Catalytic Domain
Mol. Mass.:
19175.17
Organism:
Mus musculus
Description:
gi_160707929
Residue:
168
Sequence:
MAAESLPFTLETVSSWELEAWYEDLQEVLSSDEIGGTYISSPGNEEEESKTFTTLDPASLAWLTEEPGPTEVTRTSQSPRSPDSSQSSMAQEEEEEEQGRTRKRKQSGQCPARPGKQRMKEKEQENERKVAQLAEENERLKQEIERLTREVETTRRALIDRMVSLHQA
  
Inhibitor
Name:
BDBM30762
Synonyms:
2-amino-N-butan-2-yl-1-(2-oxolanylmethyl)-3-pyrrolo[3,2-b]quinoxalinecarboxamide | 2-amino-N-butan-2-yl-1-(oxolan-2-ylmethyl)pyrrolo[3,2-b]quinoxaline-3-carboxamide | 2-amino-N-sec-butyl-1-(tetrahydrofurfuryl)pyrrolo[3,2-b]quinoxaline-3-carboxamide | 2-azanyl-N-butan-2-yl-1-(oxolan-2-ylmethyl)pyrrolo[3,2-b]quinoxaline-3-carboxamide | MLS000040979 | SMR000042875 | cid_662288
Type:
Small organic molecule
Emp. Form.:
C20H25N5O2
Mol. Mass.:
367.4448
SMILES:
CCC(C)NC(=O)c1c(N)n(CC2CCCO2)c2nc3ccccc3nc12
Structure:
Search PDB for entries with ligand similarity: