Reaction Details Report a problem with these data
Target
DNA damage-inducible transcript 3 protein
Ligand
BDBM67985
Substrate
n/a
Meas. Tech.
Dose-response primary assay and counterscreen assay for HTS small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress
IC50
9220±n/a nM
Citation
 PubChem, PC Dose-response primary assay and counterscreen assay for HTS small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress PubChem Bioassay (2010)[AID] 
Target
Name:
DNA damage-inducible transcript 3 protein
Synonyms:
Chop | Chop10 | DDIT3_MOUSE | Ddit3 | Gadd153
Type:
Enzyme Catalytic Domain
Mol. Mass.:
19175.17
Organism:
Mus musculus
Description:
gi_160707929
Residue:
168
Sequence:
MAAESLPFTLETVSSWELEAWYEDLQEVLSSDEIGGTYISSPGNEEEESKTFTTLDPASLAWLTEEPGPTEVTRTSQSPRSPDSSQSSMAQEEEEEEQGRTRKRKQSGQCPARPGKQRMKEKEQENERKVAQLAEENERLKQEIERLTREVETTRRALIDRMVSLHQA
  
Inhibitor
Name:
BDBM67985
Synonyms:
5H-pyrimid[5,4-b]indol-4-yl-[(2,4,5-trimethoxybenzylidene)amino]amine | MLS000331873 | N-(5H-Pyrimido[5,4-b]indol-4-yl)-N'-[1-(2,4,5-trimethoxy-phenyl)-meth-(E)-ylidene]-hydrazine | N-[(2,4,5-trimethoxyphenyl)methylideneamino]-5H-pyrimido[5,4-b]indol-4-amine | SMR000221363 | cid_4887198
Type:
Small organic molecule
Emp. Form.:
C20H19N5O3
Mol. Mass.:
377.3966
SMILES:
COc1cc(OC)c(OC)cc1CN=Nc1ncnc2c3ccccc3[nH]c12 |w:14.15|
Structure:
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