Reaction Details Report a problem with these data
Target
DNA damage-inducible transcript 3 protein
Ligand
BDBM68002
Substrate
n/a
Meas. Tech.
Dose-response primary assay and counterscreen assay for HTS small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress
IC50
4760±n/a nM
Citation
 PubChem, PC Dose-response primary assay and counterscreen assay for HTS small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress PubChem Bioassay (2010)[AID] 
Target
Name:
DNA damage-inducible transcript 3 protein
Synonyms:
Chop | Chop10 | DDIT3_MOUSE | Ddit3 | Gadd153
Type:
Enzyme Catalytic Domain
Mol. Mass.:
19175.17
Organism:
Mus musculus
Description:
gi_160707929
Residue:
168
Sequence:
MAAESLPFTLETVSSWELEAWYEDLQEVLSSDEIGGTYISSPGNEEEESKTFTTLDPASLAWLTEEPGPTEVTRTSQSPRSPDSSQSSMAQEEEEEEQGRTRKRKQSGQCPARPGKQRMKEKEQENERKVAQLAEENERLKQEIERLTREVETTRRALIDRMVSLHQA
  
Inhibitor
Name:
BDBM68002
Synonyms:
2-[benzyl-[2-(1,1,3-triketo-1,2-benzothiazol-2-yl)acetyl]amino]-N-cyclohexyl-2-(4-fluorophenyl)acetamide | 2-[benzyl-[2-(1,1,3-trioxo-1,2-benzothiazol-2-yl)acetyl]amino]-N-cyclohexyl-2-(4-fluorophenyl)acetamide | 2-{Benzyl-[2-(1,1,3-trioxo-1,3-dihydro-1lambda*6*-benzo[d]isothiazol-2-yl)-acetyl]-amino}-N-cyclohexyl-2-(4-fluoro-phenyl)-acetamide | MLS000554579 | N-cyclohexyl-2-(4-fluorophenyl)-2-[(phenylmethyl)-[2-[1,1,3-tris(oxidanylidene)-1,2-benzothiazol-2-yl]ethanoyl]amino]ethanamide | N-cyclohexyl-2-(4-fluorophenyl)-2-[[1-oxo-2-(1,1,3-trioxo-1,2-benzothiazol-2-yl)ethyl]-(phenylmethyl)amino]acetamide | SMR000170943 | cid_3184644
Type:
Small organic molecule
Emp. Form.:
C30H30FN3O5S
Mol. Mass.:
563.64
SMILES:
Fc1ccc(cc1)C(N(Cc1ccccc1)C(=O)CN1C(=O)c2ccccc2S1(=O)=O)C(=O)NC1CCCCC1
Structure:
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