Reaction Details Report a problem with these data
Target
Heat shock factor protein 1
Ligand
BDBM72757
Substrate
n/a
Meas. Tech.
Luminescence Cell-Based Dose Retest to Identify Potentiators of Heat Shock Factor 1 (HSF1)
EC50
14640±n/a nM
Citation
 PubChem, PC Luminescence Cell-Based Dose Retest to Identify Potentiators of Heat Shock Factor 1 (HSF1) PubChem Bioassay (2010)[AID] 
Target
Name:
Heat shock factor protein 1
Synonyms:
HSF1_MOUSE | Hsf1 | Hsf1 protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57208.68
Organism:
Mus musculus
Description:
P38532
Residue:
525
Sequence:
MDLAVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKYFKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVTSVSTLKSEDIKIRQDSVTRLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHAQQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLSDSNSAHSVPKYGRQYSLEHVHGPGPYSAPSPAYSSSSLYSSDAVTSSGPIISDITELAPTSPLASPGRSIDERPLSSSTLVRVKQEPPSPPHSPRVLEASPGRPSSMDTPLSPTAFIDSILRESEPTPAASNTAPMDTTGAQAPALPTPSTPEKCLSVACLDKNELSDHLDAMDSNLDNLQTMLTSHGFSVDTSALLDLFSPSVTMPDMSLPDLDSSLASIQELLSPQEPPRPIEAENSNPDSGKQLVHYTAQPLFLLDPDAVDTGSSELPVLFELGESSYFSEGDDYTDDPTISLLTGTEPHKAKDPTVS
  
Inhibitor
Name:
BDBM72757
Synonyms:
5-(2-methylquinolin-4-yl)sulfanyl-1,3,4-thiadiazol-2-amine | 5-[(2-methyl-4-quinolinyl)thio]-1,3,4-thiadiazol-2-amine | 5-[(2-methyl-4-quinolyl)thio]-1,3,4-thiadiazol-2-amine | MLS000833687 | SMR000457208 | [5-[(2-methyl-4-quinolyl)thio]-1,3,4-thiadiazol-2-yl]amine | cid_2799527
Type:
Small organic molecule
Emp. Form.:
C12H10N4S2
Mol. Mass.:
274.365
SMILES:
Cc1cc(Sc2nnc(N)s2)c2ccccc2n1
Structure:
Search PDB for entries with ligand similarity: