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Target
Importin subunit alpha-1
Ligand
BDBM74800
Substrate
n/a
Meas. Tech.
Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex.
EC50
32000±n/a nM
Citation
 PubChem, PC Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex. PubChem Bioassay (2010)[AID] 
Target
Name:
Importin subunit alpha-1
Synonyms:
IMA1_HUMAN | KPNA2 | RCH1 | SRP1 | karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57852.15
Organism:
Homo sapiens (Human)
Description:
gi_119609447
Residue:
529
Sequence:
MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF
  
Inhibitor
Name:
BDBM74800
Synonyms:
1-[2-(3-Cyano-8-methyl-quinolin-2-ylamino)-ethyl]-3-(3-ethoxy-propyl)-thiourea | 1-[2-[(3-cyano-8-methyl-2-quinolinyl)amino]ethyl]-3-(3-ethoxypropyl)thiourea | 1-[2-[(3-cyano-8-methyl-2-quinolyl)amino]ethyl]-3-(3-ethoxypropyl)thiourea | 1-[2-[(3-cyano-8-methyl-quinolin-2-yl)amino]ethyl]-3-(3-ethoxypropyl)thiourea | 1-[2-[(3-cyano-8-methylquinolin-2-yl)amino]ethyl]-3-(3-ethoxypropyl)thiourea | MLS000557041 | SMR000173448 | cid_3221589
Type:
Small organic molecule
Emp. Form.:
C19H25N5OS
Mol. Mass.:
371.5
SMILES:
CCOCCCNC(=S)NCCNc1nc2c(C)cccc2cc1C#N
Structure:
Search PDB for entries with ligand similarity: