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Target
Importin subunit alpha-1
Ligand
BDBM75245
Substrate
n/a
Meas. Tech.
Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex.
EC50
135400±n/a nM
Citation
 PubChem, PC Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex. PubChem Bioassay (2010)[AID] 
Target
Name:
Importin subunit alpha-1
Synonyms:
IMA1_HUMAN | KPNA2 | RCH1 | SRP1 | karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57852.15
Organism:
Homo sapiens (Human)
Description:
gi_119609447
Residue:
529
Sequence:
MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF
  
Inhibitor
Name:
BDBM75245
Synonyms:
4-phenyl-N-[2-[1-(3,3,3-trifluoro-1-methyl-propyl)-4-piperidyl]pyrazol-3-yl]butyramide | 4-phenyl-N-[2-[1-(4,4,4-trifluorobutan-2-yl)-4-piperidinyl]-3-pyrazolyl]butanamide | 4-phenyl-N-[2-[1-(4,4,4-trifluorobutan-2-yl)piperidin-4-yl]pyrazol-3-yl]butanamide | 4-phenyl-N-[2-[1-[4,4,4-tris(fluoranyl)butan-2-yl]piperidin-4-yl]pyrazol-3-yl]butanamide | MLS001105256 | SMR000664922 | cid_24791400
Type:
Small organic molecule
Emp. Form.:
C22H29F3N4O
Mol. Mass.:
422.4871
SMILES:
CC(CC(F)(F)F)N1CCC(CC1)n1nccc1NC(=O)CCCc1ccccc1
Structure:
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