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Target
Importin subunit alpha-1
Ligand
BDBM75267
Substrate
n/a
Meas. Tech.
Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex.
EC50
>500000±n/a nM
Citation
 PubChem, PC Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex. PubChem Bioassay (2010)[AID] 
Target
Name:
Importin subunit alpha-1
Synonyms:
IMA1_HUMAN | KPNA2 | RCH1 | SRP1 | karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57852.15
Organism:
Homo sapiens (Human)
Description:
gi_119609447
Residue:
529
Sequence:
MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF
  
Inhibitor
Name:
BDBM75267
Synonyms:
4-isoquinolin-2-ium-2-yl-5-[(phenylcarbonylhydrazinylidene)methyl]-1,3-thiazol-2-olate | 5-[(benzoylhydrazinylidene)methyl]-4-(2-isoquinolin-2-iumyl)-2-thiazololate | 5-[(benzoylhydrazinylidene)methyl]-4-isoquinolin-2-ium-2-yl-1,3-thiazol-2-olate | 5-[(benzoylhydrazono)methyl]-4-isoquinolin-2-ium-2-yl-thiazol-2-olate | MLS001075266 | SMR000646354 | cid_4269389
Type:
Small organic molecule
Emp. Form.:
C20H14N4O2S
Mol. Mass.:
374.416
SMILES:
O=C(N\N=C\c1sc(=O)[n-]c1-[n+]1ccc2ccccc2c1)c1ccccc1
Structure:
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