Reaction Details Report a problem with these data
Target
Furin
Ligand
BDBM66635
Substrate
n/a
Meas. Tech.
High throughput fluorescence intensity-based biochemical assay to screen for small molecule inhibitors of Furin:Concentration-response Confirmation Assays
IC50
>50000±n/a nM
Citation
 PubChem, PC High throughput fluorescence intensity-based biochemical assay to screen for small molecule inhibitors of Furin:Concentration-response Confirmation Assays PubChem Bioassay (2010)[AID] 
Target
Name:
Furin
Synonyms:
FUR | FURIN | FURIN_HUMAN | Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA | PACE | PCSK3
Type:
Enzyme Catalytic Domain
Mol. Mass.:
86676.01
Organism:
Homo sapiens (Human)
Description:
P09958
Residue:
794
Sequence:
MELRPWLLWVVAATGTLVLLAADAQGQKVFTNTWAVRIPGGPAVANSVARKHGFLNLGQIFGDYYHFWHRGVTKRSLSPHRPRHSRLQREPQVQWLEQQVAKRRTKRDVYQEPTDPKFPQQWYLSGVTQRDLNVKAAWAQGYTGHGIVVSILDDGIEKNHPDLAGNYDPGASFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGGVRMLDGEVTDAVEARSLGLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFRGVSQGRGGLGSIFVWASGNGGREHDSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQIVTTDLRQKCTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLNANDWATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKCIIDILTEPKDIGKRLEVRKTVTACLGEPNHITRLEHAQARLTLSYNRRGDLAIHLVSPMGTRSTLLAARPHDYSADGFNDWAFMTTHSWDEDPSGEWVLEIENTSEANNYGTLTKFTLVLYGTAPEGLPVPPESSGCKTLTSSQACVVCEEGFSLHQKSCVQHCPPGFAPQVLDTHYSTENDVETIRASVCAPCHASCATCQGPALTDCLSCPSHASLDPVEQTCSRQSQSSRESPPQQQPPRLPPEVEAGQRLRAGLLPSHLPEVVAGLSCAFIVLVFVTVFLVLQLRSGFSFRGVKVYTMDRGLISYKGLPPEAWQEECPSDSEEDEGRGERTAFIKDQSAL
  
Inhibitor
Name:
BDBM66635
Synonyms:
MLS000737122 | SMR000528383 | [4-[(2Z)-2-(4-amino-2-methylsulfanyl-6-oxopyrimidin-5-ylidene)hydrazinyl]phenyl]arsonic acid | [4-[(2Z)-2-(4-azanyl-2-methylsulfanyl-6-oxidanylidene-pyrimidin-5-ylidene)hydrazinyl]phenyl]arsonic acid | [4-[(2Z)-2-[4-amino-2-(methylthio)-6-oxo-5-pyrimidinylidene]hydrazinyl]phenyl]arsonic acid | [4-[(N'Z)-N'-[4-amino-6-keto-2-(methylthio)pyrimidin-5-ylidene]hydrazino]phenyl]arsonic acid | cid_5992379
Type:
Small organic molecule
Emp. Form.:
C11H12AsN5O4S
Mol. Mass.:
385.231
SMILES:
CSc1nc(N)c(N=Nc2ccc(cc2)[As](O)(O)=O)c(=O)[nH]1 |w:8.8|
Structure:
Search PDB for entries with ligand similarity: