Reaction Details Report a problem with these data
Target
Lysine-specific histone demethylase 1A [151-852]
Ligand
BDBM103901
Substrate
n/a
Meas. Tech.
Demethylase Biochemical Assay
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
<50±n/a nM
Comments
extracted
Citation
 Wu, L; Konkol, LC; Lajkiewicz, N; Lu, L; Xu, M; Yao, W; Yu, Z; Zhang, C; He, C Substituted imidazo[1,5-α]pyridines and imidazo[1,5-α]pyrazines as LSD1 inhibitors US Patent  US9695168 Publication Date 7/4/2017 
Target
Name:
Lysine-specific histone demethylase 1A [151-852]
Synonyms:
AOF2 | KDM1 | KDM1A | KDM1A_HUMAN | KIAA0601 | LSD1 | Lysine-specific histone demethylase 1A
Type:
n/a
Mol. Mass.:
77867.68
Organism:
Homo sapiens (Human)
Description:
ENZO (BML-SE544-0050) which consists of 151-852 aa
Residue:
702
Sequence:
LPPPPPQAPPEEENESEPEEPSGVEGAAFQSRLPHDRMTSQEAACFPDIISGPQQTQKVFLFIRNRTLQLWLDNPKIQLTFEATLQQLEAPYNSDTVLVHRVHSYLERHGLINFGIYKRIKPLPTKKTGKVIIIGSGVSGLAAARQLQSFGMDVTLLEARDRVGGRVATFRKGNYVADLGAMVVTGLGGNPMAVVSKQVNMELAKIKQKCPLYEANGQAVPKEKDEMVEQEFNRLLEATSYLSHQLDFNVLNNKPVSLGQALEVVIQLQEKHVKDEQIEHWKKIVKTQEELKELLNKMVNLKEKIKELHQQYKEASEVKPPRDITAEFLVKSKHRDLTALCKEYDELAETQGKLEEKLQELEANPPSDVYLSSRDRQILDWHFANLEFANATPLSTLSLKHWDQDDDFEFTGSHLTVRNGYSCVPVALAEGLDIKLNTAVRQVRYTASGCEVIAVNTRSTSQTFIYKCDAVLCTLPLGVLKQQPPAVQFVPPLPEWKTSAVQRMGFGNLNKVVLCFDRVFWDPSVNLFGHVGSTTASRGELFLFWNLYKAPILLALVAGEAAGIMENISDDVIVGRCLAILKGIFGSSAVPQPKETVVSRWRADPWARGSYSYVAAGSSGNDYDLMAQPITPGPSIPGAPQPIPRLFFAGEHTIRNYPATVHGALLSGLREAGRIADQFLGAMYTLPRQATPGVPAQQSPSM
  
Inhibitor
Name:
BDBM103901
Synonyms:
US10047086, 15 | US10640503, Example 15 | US9695168, 15
Type:
Small organic molecule
Emp. Form.:
C28H27N5O2
Mol. Mass.:
465.5463
SMILES:
CN1CCOc2ccc(cc12)-c1c(cc(OC[C@@H]2CCNC2)c2cncn12)-c1ccc(cc1)C#N |r|
Structure:
Search PDB for entries with ligand similarity: