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Target
NACHT, LRR and PYD domains-containing protein 1
Ligand
BDBM76309
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS for the identification of inhibitors of NALP1 in yeast using a luminescent assay
IC50
9660±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS for the identification of inhibitors of NALP1 in yeast using a luminescent assay PubChem Bioassay (2010)[AID] 
Target
Name:
NACHT, LRR and PYD domains-containing protein 1
Synonyms:
CARD7 | DEFCAP | KIAA0926 | NAC | NACHT, LRR and PYD domains-containing protein 1 isoform 1 | NALP1 | NLRP1 | NLRP1_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
165873.33
Organism:
Homo sapiens (Human)
Description:
Q9C000
Residue:
1473
Sequence:
MAGGAWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQYGEQRAWDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPWIHELPAGCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQESPNAPTSTAVLGSWGSPPQPSLAPREQEAPGTQWPLDETSGIYYTEIREREREKSEKGRPPWAAVVGTPPQAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSWPDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLCLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAYGIHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLHCLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWSPTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRALEQEKPQLLIFSRRKPSVMTPTEGLDTGEMSNSTSSLKRQRLGSERAASHVAQANLKLLDVSKIFPIAEIAEESSPEVVPVELLCVPSPASQGDLHTKPLGTDDDFWGPTGPVATEVVDKEKNLYRVHFPVAGSYRWPNTGLCFVMREAVTVEIEFCVWDQFLGEINPQHSWMVAGPLLDIKAEPGAVEAVHLPHFVALQGGHVDTSLFQMAHFKEEGMLLEKPARVELHHIVLENPSFSPLGVLLKMIHNALRFIPVTSVVLLYHRVHPEEVTFHLYLIPSDCSIRKAIDDLEMKFQFVRIHKPPPLTPLYMGCRYTVSGSGSGMLEILPKELELCYRSPGEDQLFSEFYVGHLGSGIRLQVKDKKDETLVWEALVKPGDLMPATTLIPPARIAVPSPLDAPQLLHFVDQYREQLIARVTSVEVVLDKLHGQVLSQEQYERVLAENTRPSQMRKLFSLSQSWDRKCKDGLYQALKETHPHLIMELWEKGSKKGLLPLSS
  
Inhibitor
Name:
BDBM76309
Synonyms:
1-[6-(4-Fluoro-phenoxy)-hexyl]-4-(2-methoxy-phenyl)-piperazine | 1-[6-(4-fluoranylphenoxy)hexyl]-4-(2-methoxyphenyl)piperazine | 1-[6-(4-fluorophenoxy)hexyl]-4-(2-methoxyphenyl)piperazine | MLS000554187 | SMR000146504 | cid_4529573
Type:
Small organic molecule
Emp. Form.:
C23H31FN2O2
Mol. Mass.:
386.5028
SMILES:
COc1ccccc1N1CCN(CCCCCCOc2ccc(F)cc2)CC1
Structure:
Search PDB for entries with ligand similarity: