Reaction Details Report a problem with these data
Target
DNA damage-inducible transcript 3 protein
Ligand
BDBM67806
Substrate
n/a
Meas. Tech.
CHOP dose-response primary assay
IC50
1420±n/a nM
Citation
 PubChem, PC CHOP dose-response primary assay PubChem Bioassay (2011)[AID] 
Target
Name:
DNA damage-inducible transcript 3 protein
Synonyms:
Chop | Chop10 | DDIT3_MOUSE | Ddit3 | Gadd153
Type:
Enzyme Catalytic Domain
Mol. Mass.:
19175.17
Organism:
Mus musculus
Description:
gi_160707929
Residue:
168
Sequence:
MAAESLPFTLETVSSWELEAWYEDLQEVLSSDEIGGTYISSPGNEEEESKTFTTLDPASLAWLTEEPGPTEVTRTSQSPRSPDSSQSSMAQEEEEEEQGRTRKRKQSGQCPARPGKQRMKEKEQENERKVAQLAEENERLKQEIERLTREVETTRRALIDRMVSLHQA
  
Inhibitor
Name:
BDBM67806
Synonyms:
5-(3-fluorobenzyl)-7-(trifluoromethyl)-3,3a-dihydro-1H-thiazolo[3,4-a]quinoxalin-4-one | 5-(3-fluorobenzyl)-7-(trifluoromethyl)-3,3a-dihydro[1,3]thiazolo[3,4-a]quinoxalin-4(5H)-one | 5-[(3-fluorophenyl)methyl]-7-(trifluoromethyl)-3,3a-dihydro-1H-[1,3]thiazolo[3,4-a]quinoxalin-4-one | 5-[(3-fluorophenyl)methyl]-7-(trifluoromethyl)-3,3a-dihydro-1H-thiazolo[3,4-a]quinoxalin-4-one | MLS000541394 | SMR000126252 | cid_3743081
Type:
Small organic molecule
Emp. Form.:
C18H14F4N2OS
Mol. Mass.:
382.375
SMILES:
Fc1cccc(CN2C(=O)C3CSCN3c3ccc(cc23)C(F)(F)F)c1
Structure:
Search PDB for entries with ligand similarity: