Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM23
Ligand
BDBM78299
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen.
IC50
9410±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen. PubChem Bioassay (2011)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM23
Synonyms:
MAS6 | MIM23 | MPI3 | TIM23 | TIM23_YEAST | TPA: Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23245.32
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285814664
Residue:
222
Sequence:
MSWLFGDKTPTDDANAAVGGQDTTKPKELSLKQSLGFEPNINNIISGPGGMHVDTARLHPLAGLDKGVEYLDLEEEQLSSLEGSQGLIPSRGWTDDLCYGTGAVYLLGLGIGGFSGMMQGLQNIPPNSPGKLQLNTVLNHITKRGPFLGNNAGILALSYNIINSTIDALRGKHDTAGSIGAGALTGALFKSSKGLKPMGYSSAMVAAACAVWCSVKKRLLEK
  
Inhibitor
Name:
BDBM78299
Synonyms:
3-(4-methoxyphenyl)-4H-pyrazol-4-one N-phenylhydrazone | MLS000695015 | N-[(E)-[3-(4-methoxyphenyl)-4-pyrazolylidene]amino]aniline | N-[(E)-[3-(4-methoxyphenyl)pyrazol-4-ylidene]amino]aniline | SMR000334641 | [(E)-[3-(4-methoxyphenyl)pyrazol-4-ylidene]amino]-phenyl-amine | cid_6367769
Type:
Small organic molecule
Emp. Form.:
C16H14N4O
Mol. Mass.:
278.3086
SMILES:
COc1ccc(cc1)-c1n[nH]cc1N=Nc1ccccc1 |w:14.16|
Structure:
Search PDB for entries with ligand similarity: