Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM10
Ligand
BDBM65290
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS small molecule inhibitors of tim23-1: a luminescent tim10-1 yeast counterscreen.
IC50
>100000±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim23-1: a luminescent tim10-1 yeast counterscreen. PubChem Bioassay (2011)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM10
Synonyms:
MRS11 | TIM10 | TIM10_YEAST | TPA: Essential protein of the mitochondrial intermembrane space | TPA: Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner ...
Type:
Enzyme Catalytic Domain
Mol. Mass.:
10303.50
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285809906
Residue:
93
Sequence:
MSFLGFGGGQPQLSSQQKIQAAEAELDLVTDMFNKLVNNCYKKCINTSYSEGELNKNESSCLDRCVAKYFETNVQVGENMQKMGQSFNAAGKF
  
Inhibitor
Name:
BDBM65290
Synonyms:
2-(2-furoylimino)-3,4-dimethyl-4-thiazoline-5-carboxylic acid ethyl ester | 2-[2-furanyl(oxo)methyl]imino-3,4-dimethyl-5-thiazolecarboxylic acid ethyl ester | MLS000678944 | SMR000323345 | cid_4576653 | ethyl 2-(furan-2-carbonylimino)-3,4-dimethyl-1,3-thiazole-5-carboxylate | ethyl 2-(furan-2-ylcarbonylimino)-3,4-dimethyl-1,3-thiazole-5-carboxylate
Type:
Small organic molecule
Emp. Form.:
C13H14N2O4S
Mol. Mass.:
294.326
SMILES:
CCOC(=O)c1s\c(=N/C(=O)c2ccco2)n(C)c1C
Structure:
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