Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM10
Ligand
BDBM77779
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS small molecule inhibitors of tim23-1: a luminescent tim10-1 yeast counterscreen.
IC50
>100000±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim23-1: a luminescent tim10-1 yeast counterscreen. PubChem Bioassay (2011)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM10
Synonyms:
MRS11 | TIM10 | TIM10_YEAST | TPA: Essential protein of the mitochondrial intermembrane space | TPA: Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner ...
Type:
Enzyme Catalytic Domain
Mol. Mass.:
10303.50
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285809906
Residue:
93
Sequence:
MSFLGFGGGQPQLSSQQKIQAAEAELDLVTDMFNKLVNNCYKKCINTSYSEGELNKNESSCLDRCVAKYFETNVQVGENMQKMGQSFNAAGKF
  
Inhibitor
Name:
BDBM77779
Synonyms:
(E)-3-amino-2-[(2-chlorobenzylidene)amino]-3-methoxy-acrylonitrile | (E)-3-amino-2-[(2-chlorophenyl)methylideneamino]-3-methoxy-2-propenenitrile | (E)-3-amino-2-[(2-chlorophenyl)methylideneamino]-3-methoxyprop-2-enenitrile | (E)-3-azanyl-2-[(2-chlorophenyl)methylideneamino]-3-methoxy-prop-2-enenitrile | 3-amino-2-{[(2-chlorophenyl)methylene]amino}-3-methoxyacrylonitrile | MLS000692010 | SMR000333690 | cid_1478418
Type:
Small organic molecule
Emp. Form.:
C11H10ClN3O
Mol. Mass.:
235.67
SMILES:
COC(=N)C(N=Cc1ccccc1Cl)C#N |w:5.4|
Structure:
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