Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM10
Ligand
BDBM77631
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS small molecule inhibitors of tim23-1: a luminescent TIM10 yeast counterscreen.
IC50
10800±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim23-1: a luminescent TIM10 yeast counterscreen. PubChem Bioassay (2011)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM10
Synonyms:
MRS11 | TIM10 | TIM10_YEAST | TPA: Essential protein of the mitochondrial intermembrane space | TPA: Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner ...
Type:
Enzyme Catalytic Domain
Mol. Mass.:
10303.50
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285809906
Residue:
93
Sequence:
MSFLGFGGGQPQLSSQQKIQAAEAELDLVTDMFNKLVNNCYKKCINTSYSEGELNKNESSCLDRCVAKYFETNVQVGENMQKMGQSFNAAGKF
  
Inhibitor
Name:
BDBM77631
Synonyms:
MLS000029810 | N-(2-Phenyl-benzooxazol-5-yl)-nicotinamide | N-(2-phenyl-1,3-benzoxazol-5-yl)-3-pyridinecarboxamide | N-(2-phenyl-1,3-benzoxazol-5-yl)nicotinamide | N-(2-phenyl-1,3-benzoxazol-5-yl)pyridine-3-carboxamide | SMR000009926 | cid_650941
Type:
Small organic molecule
Emp. Form.:
C19H13N3O2
Mol. Mass.:
315.3254
SMILES:
O=C(Nc1ccc2oc(nc2c1)-c1ccccc1)c1cccnc1
Structure:
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