Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM10
Ligand
BDBM77634
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS small molecule inhibitors of tim23-1: a luminescent TIM10 yeast counterscreen.
IC50
26800±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim23-1: a luminescent TIM10 yeast counterscreen. PubChem Bioassay (2011)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM10
Synonyms:
MRS11 | TIM10 | TIM10_YEAST | TPA: Essential protein of the mitochondrial intermembrane space | TPA: Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner ...
Type:
Enzyme Catalytic Domain
Mol. Mass.:
10303.50
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285809906
Residue:
93
Sequence:
MSFLGFGGGQPQLSSQQKIQAAEAELDLVTDMFNKLVNNCYKKCINTSYSEGELNKNESSCLDRCVAKYFETNVQVGENMQKMGQSFNAAGKF
  
Inhibitor
Name:
BDBM77634
Synonyms:
5,6,7,8-tetrafluoro-2-methyl-4-oxo-1-benzopyran-3-carboxylic acid ethyl ester | 5,6,7,8-tetrafluoro-4-keto-2-methyl-chromene-3-carboxylic acid ethyl ester | MLS000079832 | SMR000041624 | cid_660935 | ethyl 5,6,7,8-tetrafluoro-2-methyl-4-oxochromene-3-carboxylate | ethyl 5,6,7,8-tetrakis(fluoranyl)-2-methyl-4-oxidanylidene-chromene-3-carboxylate
Type:
Small organic molecule
Emp. Form.:
C13H8F4O4
Mol. Mass.:
304.1938
SMILES:
CCOC(=O)c1c(C)oc2c(F)c(F)c(F)c(F)c2c1=O
Structure:
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