Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM10
Ligand
BDBM77676
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS small molecule inhibitors of tim23-1: a luminescent TIM10 yeast counterscreen.
IC50
12400±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim23-1: a luminescent TIM10 yeast counterscreen. PubChem Bioassay (2011)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM10
Synonyms:
MRS11 | TIM10 | TIM10_YEAST | TPA: Essential protein of the mitochondrial intermembrane space | TPA: Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner ...
Type:
Enzyme Catalytic Domain
Mol. Mass.:
10303.50
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285809906
Residue:
93
Sequence:
MSFLGFGGGQPQLSSQQKIQAAEAELDLVTDMFNKLVNNCYKKCINTSYSEGELNKNESSCLDRCVAKYFETNVQVGENMQKMGQSFNAAGKF
  
Inhibitor
Name:
BDBM77676
Synonyms:
3-(2,2-dimethyl-4-oxanyl)-2-(2-hydroxyethylamino)-4-spiro[6H-benzo[h]quinazoline-5,1'-cyclopentane]one | 3-(2,2-dimethyloxan-4-yl)-2-(2-hydroxyethylamino)spiro[6H-benzo[h]quinazoline-5,1'-cyclopentane]-4-one | 3-(2,2-dimethyltetrahydropyran-4-yl)-2-(2-hydroxyethylamino)spiro[6H-benzo[h]quinazoline-5,1'-cyclopentane]-4-one | MLS000108019 | SMR000103982 | cid_2862957
Type:
Small organic molecule
Emp. Form.:
C25H33N3O3
Mol. Mass.:
423.5478
SMILES:
CC1(C)CC(CCO1)n1c(NCCO)nc2-c3ccccc3CC3(CCCC3)c2c1=O
Structure:
Search PDB for entries with ligand similarity: