Reaction Details
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DNA dC->dU-editing enzyme APOBEC-3G
Ligand
BDBM61377
Substrate
n/a
Meas. Tech.
Dose Response confirmation of APOBEC3A DNA Deaminase Inhibitors via a A3G counterscreen
Temperature
298.15±n/a K
IC50
1290±107 nM
Comments
extracted
Citation
PubChem, PC Dose Response confirmation of APOBEC3A DNA Deaminase Inhibitors via a A3G counterscreen PubChem Bioassay (2011)[AID] More Info.:
Target
Name:
DNA dC->dU-editing enzyme APOBEC-3G
Synonyms:
ABC3G_HUMAN | APOBEC3G
Type:
Enzyme Catalytic Domain
Mol. Mass.:
46419.54
Organism:
Homo sapiens (Human)
Description:
gi_13399304
Residue:
384
Sequence:
MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTKGPSRPPLDAKIFRGQVYSELKYHPEMRFFHWFSKWRKLHRDQEYEVTWYISWSPCTKCTRDMATFLAEDPKVTLTIFVARLYYFWDPDYQEALRSLCQKRDGPRATMKIMNYDEFQHCWSKFVYSQRELFEPWNNLPKYYILLHIMLGEILRHSMDPPTFTFNFNNEPWVRGRHETYLCYEVERMHNDTWVLLNQRRGFLCNQAPHKHGFLEGRHAELCFLDVIPFWKLDLDQDYRVTCFTSWSPCFSCAQEMAKFISKNKHVSLCIFTARIYDDQGRCQEGLRTLAEAGAKISIMTYSEFKHCWDTFVDHQGCPFQPWDGLDEHSQDLSGRLRAILQNQEN
Inhibitor
Name:
BDBM61377
Synonyms:
2-[2-methoxy-4-[(E)-2-(1-methyl-2-pyridin-1-iumyl)ethenyl]phenoxy]-N-(2-methylphenyl)acetamide;iodide | 2-[2-methoxy-4-[(E)-2-(1-methylpyridin-1-ium-2-yl)ethenyl]phenoxy]-N-(2-methylphenyl)acetamide;iodide | 2-[2-methoxy-4-[(E)-2-(1-methylpyridin-1-ium-2-yl)ethenyl]phenoxy]-N-(2-methylphenyl)ethanamide;iodide | 2-[2-methoxy-4-[(E)-2-(1-methylpyridin-1-ium-2-yl)vinyl]phenoxy]-N-(o-tolyl)acetamide;iodide | 2-{(E)-2-[3-Methoxy-4-(o-tolylcarbamoyl-methoxy)-phenyl]-vinyl}-1-methyl-pyridinium | MLS001216975 | SMR000605599 | cid_24792360
Type:
Small organic molecule
Emp. Form.:
C24H25N2O3
Mol. Mass.:
389.4664
SMILES:
COc1cc(\C=C\c2cccc[n+]2C)ccc1OCC(=O)Nc1ccccc1C
Structure:
