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Target
Egl nine homolog 1
Ligand
BDBM141608
Substrate
n/a
Meas. Tech.
HIF-PH Assay
pH
7.4±n/a
IC50
280±n/a nM
Comments
extracted
Citation
 Ng, D; Arend, MP; Flippin, LA Naphthyridine derivatives as inhibitors of Hypoxia inducible factor (HIF) hydroxylase US Patent  US9695170 Publication Date 7/4/2017 
Target
Name:
Egl nine homolog 1
Synonyms:
C1orf12 | EGLN1 | EGLN1_HUMAN | Egl nine homolog 1 (EGLN1) | Hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2) | Hypoxia-inducible factor prolyl hydroxylase 2 (HIFPH2) | Prolyl hydroxylase domain-containing protein 2 (PHD2)
Type:
Protein
Mol. Mass.:
46035.59
Organism:
Homo sapiens (Human)
Description:
Q9GZT9
Residue:
426
Sequence:
MANDSGGPGGPSPSERDRQYCELCGKMENLLRCSRCRSSFYCCKEHQRQDWKKHKLVCQGSEGALGHGVGPHQHSGPAPPAAVPPPRAGAREPRKAAARRDNASGDAAKGKVKAKPPADPAAAASPCRAAAGGQGSAVAAEAEPGKEEPPARSSLFQEKANLYPPSNTPGDALSPGGGLRPNGQTKPLPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTDGQLVSQKSDSSKDIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTKAMVACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADERARAKVKYLTGEKGVRVELNKPSDSVGKDVF
  
Inhibitor
Name:
BDBM141608
Synonyms:
US8921389, 64 | US9695170 64
Type:
Small organic molecule
Emp. Form.:
C20H19N3O7
Mol. Mass.:
413.3808
SMILES:
COc1ccc(Cn2ccc3c(O)c(ncc3c2=O)C(=O)NCC(O)=O)c(OC)c1
Structure:
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