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Target
Cysteine protease ATG4B
Ligand
BDBM80898
Substrate
n/a
Meas. Tech.
Dose response confirmation of the uHTS fluorescent assay for identification of inhibitors of ATG4B.
IC50
25400±n/a nM
Citation
 PubChem, PC Dose response confirmation of the uHTS fluorescent assay for identification of inhibitors of ATG4B. PubChem Bioassay (2011)[AID] 
Target
Name:
Cysteine protease ATG4B
Synonyms:
APG4B | ATG4B | ATG4B_HUMAN | AUTL1 | KIAA0943 | cysteine protease ATG4B isoform a | hck
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44279.79
Organism:
Homo sapiens (Human)
Description:
gi_47132611
Residue:
393
Sequence:
MDAATLTYDTLRFAEFEDFPETSEPVWILGRKYSIFTEKDEILSDVASRLWFTYRKNFPAIGGTGPTSDTGWGCMLRCGQMIFAQALVCRHLGRDWRWTQRKRQPDSYFSVLNAFIDRKDSYYSIHQIAQMGVGEGKSIGQWYGPNTVAQVLKKLAVFDTWSSLAVHIAMDNTVVMEEIRRLCRTSVPCAGATAFPADSDRHCNGFPAGAEVTNRPSPWRPLVLLIPLRLGLTDINEAYVETLKHCFMMPQSLGVIGGKPNSAHYFIGYVGEELIYLDPHTTQPAVEPTDGCFIPDESFHCQHPPCRMSIAELDPSIAVGFFCKTEDDFNDWCQQVKKLSLLGGALPMFELVELQPSHLACPDVLNLSLDSSDVERLERFFDSEDEDFEILSL
  
Inhibitor
Name:
BDBM80898
Synonyms:
1-(phenylmethyl)-3-[4-(trifluoromethoxy)phenyl]thiourea | 1-(phenylmethyl)-3-[4-(trifluoromethyloxy)phenyl]thiourea | 1-Benzyl-3-(4-trifluoromethoxy-phenyl)-thiourea | 1-benzyl-3-[4-(trifluoromethoxy)phenyl]thiourea | MLS000591733 | SMR000218741 | cid_948150
Type:
Small organic molecule
Emp. Form.:
C15H13F3N2OS
Mol. Mass.:
326.337
SMILES:
FC(F)(F)Oc1ccc(NC(=S)NCc2ccccc2)cc1
Structure:
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