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Target
Cysteine protease ATG4B
Ligand
BDBM80961
Substrate
n/a
Meas. Tech.
Dose response confirmation of the uHTS fluorescent assay for identification of inhibitors of ATG4B.
IC50
9330±n/a nM
Citation
 PubChem, PC Dose response confirmation of the uHTS fluorescent assay for identification of inhibitors of ATG4B. PubChem Bioassay (2011)[AID] 
Target
Name:
Cysteine protease ATG4B
Synonyms:
APG4B | ATG4B | ATG4B_HUMAN | AUTL1 | KIAA0943 | cysteine protease ATG4B isoform a | hck
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44279.79
Organism:
Homo sapiens (Human)
Description:
gi_47132611
Residue:
393
Sequence:
MDAATLTYDTLRFAEFEDFPETSEPVWILGRKYSIFTEKDEILSDVASRLWFTYRKNFPAIGGTGPTSDTGWGCMLRCGQMIFAQALVCRHLGRDWRWTQRKRQPDSYFSVLNAFIDRKDSYYSIHQIAQMGVGEGKSIGQWYGPNTVAQVLKKLAVFDTWSSLAVHIAMDNTVVMEEIRRLCRTSVPCAGATAFPADSDRHCNGFPAGAEVTNRPSPWRPLVLLIPLRLGLTDINEAYVETLKHCFMMPQSLGVIGGKPNSAHYFIGYVGEELIYLDPHTTQPAVEPTDGCFIPDESFHCQHPPCRMSIAELDPSIAVGFFCKTEDDFNDWCQQVKKLSLLGGALPMFELVELQPSHLACPDVLNLSLDSSDVERLERFFDSEDEDFEILSL
  
Inhibitor
Name:
BDBM80961
Synonyms:
2-chloranyl-5-(2-fluoren-9-ylidenehydrazinyl)benzoic acid | 2-chloro-5-(2-fluoren-9-ylidenehydrazinyl)benzoic acid | 2-chloro-5-(N'-fluoren-9-ylidenehydrazino)benzoic acid | 2-chloro-5-[2-(9-fluorenylidene)hydrazinyl]benzoic acid | MLS001173792 | SMR000591118 | cid_5114648
Type:
Small organic molecule
Emp. Form.:
C20H13ClN2O2
Mol. Mass.:
348.782
SMILES:
[#8]-[#6](=O)-c1cc(-[#7]\[#7]=[#6]-2/c3ccccc3-c3ccccc-23)ccc1Cl
Structure:
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