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Target
Lanosterol 14-alpha-demethylase
Ligand
BDBM81298
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
6±0
Kd
9e+1±n/a nM
Citation
 Lepesheva, GI; Ott, RD; Hargrove, TY; Kleshchenko, YY; Schuster, I; Nes, WD; Hill, GC; Villalta, F; Waterman, MR Sterol 14alpha-demethylase as a potential target for antitrypanosomal therapy: enzyme inhibition and parasite cell growth. Chem Biol 14:1283-93 (2007) [PubMed]  Article 
Target
Name:
Lanosterol 14-alpha-demethylase
Synonyms:
Lanosterol 14-alpha demethylase | Sterol 14-alpha demethylase (CYP51)
Type:
Protein
Mol. Mass.:
54377.77
Organism:
Trypanosoma brucei
Description:
Q385E8
Residue:
481
Sequence:
MLLEVAIFLLTALALYSFYFVKSFNVTRPTDPPVYPVTVPILGHIIQFGKSPLGFMQECKRQLKSGIFTINIVGKRVTIVGDPHEHSRFFLPRNEVLSPREVYSFMVPVFGEGVAYAAPYPRMREQLNFLAEELTIAKFQNFVPAIQHEVRKFMAANWDKDEGEINLLEDCSTMIINTACQCLFGEDLRKRLDARRFAQLLAKMESSLIPAAVFLPILLKLPLPQSARCHEARTELQKILSEIIIARKEEEVNKDSSTSDLLSGLLSAVYRDGTPMSLHEVCGMIVAAMFAGQHTSSITTTWSMLHLMHPANVKHLEALRKEIEEFPAQLNYNNVMDEMPFAERCARESIRRDPPLLMLMRKVMADVKVGSYVVPKGDIIACSPLLSHHDEEAFPEPRRWDPERDEKVEGAFIGFGAGVHKCIGQKFGLLQVKTILATAFRSYDFQLLRDEVPDPDYHTMVVGPTASQCRVKYIRRKAAAA
  
Inhibitor
Name:
BDBM81298
Synonyms:
Azole, 2
Type:
Small organic molecule
Emp. Form.:
C20H16Cl2N5O2
Mol. Mass.:
429.279
SMILES:
Clc1ccc(C(C[NH+]2C=CN=C2)NC(=O)c2nnc(o2)-c2ccccc2)c(Cl)c1 |c:8,10|
Structure:
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