Reaction Details Report a problem with these data
Target
Putative farnesyl pyrophosphate synthase
Ligand
BDBM81349
Substrate
n/a
Meas. Tech.
Enzymatic Assay
pH
7.7±0
Temperature
310.15±0 K
Ki
1.60±0.26 nM
IC50
52.7±7.6 nM
Citation
 Artz, JD; Dunford, JE; Arrowood, MJ; Dong, A; Chruszcz, M; Kavanagh, KL; Minor, W; Russell, RG; Ebetino, FH; Oppermann, U; Hui, R Targeting a uniquely nonspecific prenyl synthase with bisphosphonates to combat cryptosporidiosis. Chem Biol 15:1296-306 (2008) [PubMed]  Article 
Target
Name:
Putative farnesyl pyrophosphate synthase
Synonyms:
n/a
Type:
Enzyme
Mol. Mass.:
44960.82
Organism:
Cryptosporidium parvum
Description:
Belongs to the FPP/GGPP synthase family. Q5CR09
Residue:
384
Sequence:
ILFHLLKITFIDSIFFALHDNYLTPQFIFNKMNDLQIEYDYTDFINYYDKFKVIVYNVLKKLPLNDEIRKPVIEYYLNCIDYNVKKGKHIRGKILVLISSLSSAYSNIKRDSIYLLGWVVEAIQALILIADDIMDSGKFRRGAPCWYIVHGQSNAINDIFFLKMLSLSLIFELSSVFGNDIVMKIQKIYNESIFFTVLGQHLDLSYFDLSKADKISERYFSMVEMKTSRYTFYMPVFFGLTLSEIQVSSAQLNLIEAILYKLGEFYQVHNDVSDYLFNDSNADDICRFKLTWPLQKSFEIADEEMKLKISENYGKNSSLVKDCYNLLKINEHYLEYQRNALDYLIKLVKDITDDSLQKVFIHLIHQISELITNSRSNADSNNSL
  
Inhibitor
Name:
BDBM81349
Synonyms:
IBAN
Type:
Small organic molecule
Emp. Form.:
C10H25NO7P2
Mol. Mass.:
333.2555
SMILES:
CCCCCN(C)CCCC(O)(P(O)(O)=O)P(O)(O)=O
Structure:
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