Reaction Details Report a problem with these data
Target
Putative farnesyl pyrophosphate synthase
Ligand
BDBM12576
Substrate
n/a
Meas. Tech.
Enzymatic Assay
pH
7.7±0
Temperature
310.15±0 K
Ki
0.38±0.12 nM
IC50
45.7±2.6 nM
Citation
 Artz, JD; Dunford, JE; Arrowood, MJ; Dong, A; Chruszcz, M; Kavanagh, KL; Minor, W; Russell, RG; Ebetino, FH; Oppermann, U; Hui, R Targeting a uniquely nonspecific prenyl synthase with bisphosphonates to combat cryptosporidiosis. Chem Biol 15:1296-306 (2008) [PubMed]  Article 
Target
Name:
Putative farnesyl pyrophosphate synthase
Synonyms:
n/a
Type:
Enzyme
Mol. Mass.:
44960.82
Organism:
Cryptosporidium parvum
Description:
Belongs to the FPP/GGPP synthase family. Q5CR09
Residue:
384
Sequence:
ILFHLLKITFIDSIFFALHDNYLTPQFIFNKMNDLQIEYDYTDFINYYDKFKVIVYNVLKKLPLNDEIRKPVIEYYLNCIDYNVKKGKHIRGKILVLISSLSSAYSNIKRDSIYLLGWVVEAIQALILIADDIMDSGKFRRGAPCWYIVHGQSNAINDIFFLKMLSLSLIFELSSVFGNDIVMKIQKIYNESIFFTVLGQHLDLSYFDLSKADKISERYFSMVEMKTSRYTFYMPVFFGLTLSEIQVSSAQLNLIEAILYKLGEFYQVHNDVSDYLFNDSNADDICRFKLTWPLQKSFEIADEEMKLKISENYGKNSSLVKDCYNLLKINEHYLEYQRNALDYLIKLVKDITDDSLQKVFIHLIHQISELITNSRSNADSNNSL
  
Inhibitor
Name:
BDBM12576
Synonyms:
Bisphosphonate 1 | CHEMBL923 | JMC515594 Compound 64 | RIS | Risdronate | US11279719, Example Risedronic acid RIS | [1-hydroxy-1-phosphono-2-(pyridin-3-yl)ethyl]phosphonic acid
Type:
Small organic molecule
Emp. Form.:
C7H11NO7P2
Mol. Mass.:
283.1123
SMILES:
OC(Cc1cccnc1)(P(O)(O)=O)P(O)(O)=O
Structure:
Search PDB for entries with ligand similarity: