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Target
Alpha-2B adrenergic receptor
Ligand
BDBM66983
Substrate
n/a
Ki
42±n/a nM
Comments
PDSP_1727
Citation
 Hieble, JP; DeMarinis, RM; Fowler, PJ; Matthews, WD Selective alpha-2 adrenoceptor blockade by SK&F 86466: in vitro characterization of receptor selectivity. J Pharmacol Exp Ther 236:90-6 (1986) [PubMed] 
Target
Name:
Alpha-2B adrenergic receptor
Synonyms:
Alpha 2B adrenergic receptor | adrenergic Alpha2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42242.60
Organism:
Dog
Description:
Q2MDQ0
Residue:
387
Sequence:
AIAAVITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELLGYWYFRRTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRTPRRIKCIILTVWLIAAVISLPPLIYKGDQGPQPRGRPQCKLNQEAWYILASSIGSFFAPCLIMILVYLRIYLIAKRSHRRGPRAAGGRGEGESKQPHSVPTAASTKLPTLASLAASGEANGHSKPTGEKEEGDTSEDPGTPALPPSWSAVPNPGQSQKEGVCGASPEEEAEMEEGEEECEPQALPASPAAACSPPLRQPQGSRVLATLRGQVLLGRGVGTTSGQWWRRRAQLTREKRFTFVLAVVIGVFVLCWFPFFFSYSLGAICPQHCKVPHG
  
Inhibitor
Name:
BDBM66983
Synonyms:
6-chloranyl-3-methyl-1,2,4,5-tetrahydro-3-benzazepine;hydrochloride | 6-chloro-3-methyl-1,2,4,5-tetrahydro-3-benzazepine;hydrochloride | CHEMBL123349 | MLS002172470 | SKF 86466 | SKF-86466 hydrochloride | SMR001254100 | cid_10220250
Type:
Small organic molecule
Emp. Form.:
C11H14ClN
Mol. Mass.:
195.689
SMILES:
CN1CCc2cccc(Cl)c2CC1
Structure:
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