Reaction Details Report a problem with these data
Target
D(2) dopamine receptor
Ligand
BDBM11638
Substrate
n/a
Ki
1200±n/a nM
Comments
PDSP_1784
Citation
 Zahniser, NR; Dubocovich, ML Comparison of dopamine receptor sites labeled by [3H]-S-sulpiride and [3H]-spiperone in striatum. J Pharmacol Exp Ther 227:592-9 (1983) [PubMed] 
Target
Name:
D(2) dopamine receptor
Synonyms:
DOPAMINE D2 | DRD2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
50660.69
Organism:
RABBIT
Description:
DOPAMINE D2 DRD2 RABBIT::G1T1Q0
Residue:
443
Sequence:
MDPLNLSWYDEDLERQNWSRPLNGSEGRGDRPHYNYYAMLLTLLIFVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRVHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSLTISCPLLFGLNKTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLRAPLKGNCTHPEDRTLGTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
  
Inhibitor
Name:
BDBM11638
Synonyms:
CHEMBL26 | Compound 7 | N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoylbenzamide | SULPIRIDE,(+) | SULPIRIDE,(-) | Sulpiride | Sulpiride, SLP | Sulpiride-R | US10172837, Sulpiride
Type:
Small organic molecule
Emp. Form.:
C15H23N3O4S
Mol. Mass.:
341.426
SMILES:
CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(N)(=O)=O
Structure:
Search PDB for entries with ligand similarity: