Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 2C
Ligand
BDBM50280934
Substrate
n/a
Ki
363.07±n/a nM
Comments
PDSP_1803
Citation
Millan, MJ; Canton, H; Gobert, A; Lejeune, F; Rivet, JM; Bervoets, K; Brocco, M; Widdowson, P; Mennini, T; Audinot, V Novel benzodioxopiperazines acting as antagonists at postsynaptic 5-HT1A receptors and as agonists at 5-HT1A autoreceptors: a comparative pharmacological characterization with proposed 5-HT1A antagonists. J Pharmacol Exp Ther 268:337-52 (1994) [PubMed]
More Info.:
Target
Name:
5-hydroxytryptamine receptor 2C
Synonyms:
5-HT2C | HTR2C
Type:
Enzyme Catalytic Domain
Mol. Mass.:
51519.58
Organism:
PIG
Description:
G7ZKZ7
Residue:
457
Sequence:
MVNLRKAVHSFLVHLIGLLVWQCDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIILTIGGNILVIMAVSLEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAVRGPVEHSRFNSRTKAIMKIAIVWAISLGVSVPIPVIGLRDEDKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIHVLRRQALMLLRGHTEEPPGISLDFLKCCKRNTDEESAANPNQDLNPRRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCGKACNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKVYRRAFSNYLRCNYKADKKPPIRQIPRVAATALSGRELNVNIYRHTNEPVIKKADDNEPGIEMQVENLELPVNPSNVVSERISSV
Inhibitor
Name:
BDBM50280934
Synonyms:
1-tert-Butylamino-3-(thiochroman-8-yloxy)-propan-2-ol | 1-tert-Butylamino-3-(thiochroman-8-yloxy)-propan-2-ol(TERtatolol) | CHEMBL434200 | TERTATOLOL(-) | Tertatolol
Type:
Small organic molecule
Emp. Form.:
C16H25NO2S
Mol. Mass.:
295.44
SMILES:
CC(C)(C)NCC(O)COc1cccc2CCCSc12