Reaction Details Report a problem with these data
Target
Phospholipase A2
Ligand
BDBM54372
Substrate
n/a
Meas. Tech.
Dose response counterscreen of uHTS hits for ATG4B inhibitors in a Phospholipase A2 assay
IC50
2470±n/a nM
Citation
 PubChem, PC Dose response counterscreen of uHTS hits for ATG4B inhibitors in a Phospholipase A2 assay PubChem Bioassay (2011)[AID] 
Target
Name:
Phospholipase A2
Synonyms:
Group IB phospholipase A2 | PA21B_HUMAN | PLA2 | PLA2A | PLA2G1B | PPLA2 | Phosphatidylcholine 2-acylhydrolase 1B | Phospholipase A2 (PLA2) | Phospholipase A2 group 1B | phospholipase A2 precursor
Type:
Protein
Mol. Mass.:
16364.13
Organism:
Homo sapiens (Human)
Description:
P04054
Residue:
148
Sequence:
MKLLVLAVLLTVAAADSGISPRAVWQFRKMIKCVIPGSDPFLEYNNYGCYCGLGGSGTPVDELDKCCQTHDNCYDQAKKLDSCKFLLDNPYTHTYSYSCSGSAITCSSKNKECEAFICNCDRNAAICFSKAPYNKAHKNLDTKKYCQS
  
Inhibitor
Name:
BDBM54372
Synonyms:
(5Z)-5-[(6-methoxy-2-piperidin-1-yl-quinolin-3-yl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one | (5Z)-5-[(6-methoxy-2-piperidin-1-ylquinolin-3-yl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one | (5Z)-5-[(6-methoxy-2-piperidino-3-quinolyl)methylene]-2-thioxo-thiazolidin-4-one | (5Z)-5-[[6-methoxy-2-(1-piperidinyl)-3-quinolinyl]methylidene]-2-sulfanylidene-4-thiazolidinone | 5-[1-(6-Methoxy-2-piperidin-1-yl-quinolin-3-yl)-meth-(Z)-ylidene]-2-thioxo-thiazolidin-4-one | MLS001047279 | SMR000427674 | cid_1385343
Type:
Small organic molecule
Emp. Form.:
C19H19N3O2S2
Mol. Mass.:
385.503
SMILES:
COc1ccc2nc(N3CCCCC3)c(C=C3SC(S)=NC3=O)cc2c1 |w:15.15,c:20|
Structure:
Search PDB for entries with ligand similarity: