Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM34832
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay
EC50
44400±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM34832
Synonyms:
5-[(1-cyclopropyl-2,5-dimethyl-1H-pyrrol-3-yl)methylene]-1,3-diethyl-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione | 5-[(1-cyclopropyl-2,5-dimethyl-3-pyrrolyl)methylidene]-1,3-diethyl-2-sulfanylidene-1,3-diazinane-4,6-dione | 5-[(1-cyclopropyl-2,5-dimethyl-pyrrol-3-yl)methylene]-1,3-diethyl-2-thioxo-hexahydropyrimidine-4,6-quinone | 5-[(1-cyclopropyl-2,5-dimethyl-pyrrol-3-yl)methylidene]-1,3-diethyl-2-sulfanylidene-1,3-diazinane-4,6-dione | 5-[(1-cyclopropyl-2,5-dimethylpyrrol-3-yl)methylidene]-1,3-diethyl-2-sulfanylidene-1,3-diazinane-4,6-dione | MLS000666147 | SMR000271442 | cid_804077
Type:
Small organic molecule
Emp. Form.:
C18H23N3O2S
Mol. Mass.:
345.459
SMILES:
[#6]-[#6]-[#7]-1-[#6](=S)-[#7](-[#6]-[#6])-[#6](=O)\[#6](=[#6]/c2cc(-[#6])n(-[#6]-3-[#6]-[#6]-3)c2-[#6])-[#6]-1=O
Structure:
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