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Target
Orotidine 5'-phosphate decarboxylase
Ligand
BDBM83724
Substrate
n/a
Meas. Tech.
Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter
EC50
>59640±n/a nM
Citation
 PubChem, PC Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter PubChem Bioassay (2011)[AID] 
Target
Name:
Orotidine 5'-phosphate decarboxylase
Synonyms:
FXN frataxin | PYRF_ASPNG | pyrA | pyrG
Type:
Enzyme Catalytic Domain
Mol. Mass.:
30195.13
Organism:
Aspergillus niger
Description:
gi_2395
Residue:
277
Sequence:
MSSKSQLTYTARASKHPNALAKRLFEIAEAKKTNVTVSADVTTTKELLDLADRLGPYIAVIKTHIDILSDFSDETIEGLKALAQKHNFLIFEDRKFIDIGNTVQKQYHRGTLRISEWAHIINCSILPGEGIVEALAQTASAPDFSYGPERGLLILAEMTSKGSLATGQYTTSSVDYARKYKNFVMGFVSTRSLGEVQSEVSSPSDEEDFVVFTTGVNISSKGDKLGQQYQTPASAIGRGADFIIAGRGIYAAPDPVQAAQQYQKEGWEAYLARVGGN
  
Inhibitor
Name:
BDBM83724
Synonyms:
7-Butyl-8-(4-chloro-benzylsulfanyl)-3-methyl-3,7-dihydro-purine-2,6-dione | 7-butyl-8-[(4-chlorobenzyl)thio]-3-methyl-xanthine | 7-butyl-8-[(4-chlorophenyl)methylsulfanyl]-3-methyl-purine-2,6-dione | 7-butyl-8-[(4-chlorophenyl)methylsulfanyl]-3-methylpurine-2,6-dione | 7-butyl-8-[(4-chlorophenyl)methylthio]-3-methylpurine-2,6-dione | MLS000071617 | SMR000009753 | cid_651471
Type:
Small organic molecule
Emp. Form.:
C17H19ClN4O2S
Mol. Mass.:
378.876
SMILES:
CCCCn1c(SCc2ccc(Cl)cc2)nc2n(C)c(=O)[nH]c(=O)c12
Structure:
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