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Target
Orotidine 5'-phosphate decarboxylase
Ligand
BDBM83727
Substrate
n/a
Meas. Tech.
Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter
EC50
>59667±n/a nM
Citation
 PubChem, PC Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter PubChem Bioassay (2011)[AID] 
Target
Name:
Orotidine 5'-phosphate decarboxylase
Synonyms:
FXN frataxin | PYRF_ASPNG | pyrA | pyrG
Type:
Enzyme Catalytic Domain
Mol. Mass.:
30195.13
Organism:
Aspergillus niger
Description:
gi_2395
Residue:
277
Sequence:
MSSKSQLTYTARASKHPNALAKRLFEIAEAKKTNVTVSADVTTTKELLDLADRLGPYIAVIKTHIDILSDFSDETIEGLKALAQKHNFLIFEDRKFIDIGNTVQKQYHRGTLRISEWAHIINCSILPGEGIVEALAQTASAPDFSYGPERGLLILAEMTSKGSLATGQYTTSSVDYARKYKNFVMGFVSTRSLGEVQSEVSSPSDEEDFVVFTTGVNISSKGDKLGQQYQTPASAIGRGADFIIAGRGIYAAPDPVQAAQQYQKEGWEAYLARVGGN
  
Inhibitor
Name:
BDBM83727
Synonyms:
2-(2-Isopropyl-5,6-dimethyl-thieno[2,3-d]pyrimidin-4-ylsulfanyl)-N-(5-methyl-isoxazol-3-yl)-acetamide | 2-(5,6-dimethyl-2-propan-2-yl-thieno[2,3-d]pyrimidin-4-yl)sulfanyl-N-(5-methyl-1,2-oxazol-3-yl)ethanamide | 2-(5,6-dimethyl-2-propan-2-ylthieno[2,3-d]pyrimidin-4-yl)sulfanyl-N-(5-methyl-1,2-oxazol-3-yl)acetamide | 2-[(2-isopropyl-5,6-dimethyl-thieno[2,3-d]pyrimidin-4-yl)thio]-N-(5-methylisoxazol-3-yl)acetamide | 2-[(5,6-dimethyl-2-propan-2-yl-4-thieno[2,3-d]pyrimidinyl)thio]-N-(5-methyl-3-isoxazolyl)acetamide | MLS000077104 | SMR000003770 | cid_655538
Type:
Small organic molecule
Emp. Form.:
C17H20N4O2S2
Mol. Mass.:
376.496
SMILES:
CC(C)c1nc(SCC(=O)Nc2cc(C)on2)c2c(C)c(C)sc2n1
Structure:
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