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Target
Orotidine 5'-phosphate decarboxylase
Ligand
BDBM30698
Substrate
n/a
Meas. Tech.
Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter
EC50
>59591±n/a nM
Citation
 PubChem, PC Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter PubChem Bioassay (2011)[AID] 
Target
Name:
Orotidine 5'-phosphate decarboxylase
Synonyms:
FXN frataxin | PYRF_ASPNG | pyrA | pyrG
Type:
Enzyme Catalytic Domain
Mol. Mass.:
30195.13
Organism:
Aspergillus niger
Description:
gi_2395
Residue:
277
Sequence:
MSSKSQLTYTARASKHPNALAKRLFEIAEAKKTNVTVSADVTTTKELLDLADRLGPYIAVIKTHIDILSDFSDETIEGLKALAQKHNFLIFEDRKFIDIGNTVQKQYHRGTLRISEWAHIINCSILPGEGIVEALAQTASAPDFSYGPERGLLILAEMTSKGSLATGQYTTSSVDYARKYKNFVMGFVSTRSLGEVQSEVSSPSDEEDFVVFTTGVNISSKGDKLGQQYQTPASAIGRGADFIIAGRGIYAAPDPVQAAQQYQKEGWEAYLARVGGN
  
Inhibitor
Name:
BDBM30698
Synonyms:
2-(2,4-dimethoxyanilino)-7-keto-N-(tetrahydrofurfuryl)chromene-3-carboxamide | 2-(2,4-dimethoxyanilino)-7-oxo-N-(2-oxolanylmethyl)-1-benzopyran-3-carboxamide | 2-(2,4-dimethoxyanilino)-7-oxo-N-(oxolan-2-ylmethyl)chromene-3-carboxamide | 2-[(2,4-dimethoxyphenyl)amino]-7-oxidanylidene-N-(oxolan-2-ylmethyl)chromene-3-carboxamide | 2-[(Z)-2,4-Dimethoxy-phenylimino]-7-hydroxy-2H-chromene-3-carboxylic acid (tetrahydro-furan-2-ylmethyl)-amide | MLS000072508 | SMR000002220 | cid_656123
Type:
Small organic molecule
Emp. Form.:
C23H24N2O6
Mol. Mass.:
424.4465
SMILES:
COc1ccc(Nc2oc3cc(=O)ccc3cc2C(=O)NCC2CCCO2)c(OC)c1
Structure:
Search PDB for entries with ligand similarity: