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Target
Orotidine 5'-phosphate decarboxylase
Ligand
BDBM30711
Substrate
n/a
Meas. Tech.
Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter
EC50
>59648±n/a nM
Citation
 PubChem, PC Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter PubChem Bioassay (2011)[AID] 
Target
Name:
Orotidine 5'-phosphate decarboxylase
Synonyms:
FXN frataxin | PYRF_ASPNG | pyrA | pyrG
Type:
Enzyme Catalytic Domain
Mol. Mass.:
30195.13
Organism:
Aspergillus niger
Description:
gi_2395
Residue:
277
Sequence:
MSSKSQLTYTARASKHPNALAKRLFEIAEAKKTNVTVSADVTTTKELLDLADRLGPYIAVIKTHIDILSDFSDETIEGLKALAQKHNFLIFEDRKFIDIGNTVQKQYHRGTLRISEWAHIINCSILPGEGIVEALAQTASAPDFSYGPERGLLILAEMTSKGSLATGQYTTSSVDYARKYKNFVMGFVSTRSLGEVQSEVSSPSDEEDFVVFTTGVNISSKGDKLGQQYQTPASAIGRGADFIIAGRGIYAAPDPVQAAQQYQKEGWEAYLARVGGN
  
Inhibitor
Name:
BDBM30711
Synonyms:
2-amino-1-cyclohexyl-3-pyrrolo[3,2-b]quinoxalinecarbonitrile | 2-amino-1-cyclohexyl-pyrrolo[3,2-b]quinoxaline-3-carbonitrile | 2-amino-1-cyclohexylpyrrolo[3,2-b]quinoxaline-3-carbonitrile | 2-azanyl-1-cyclohexyl-pyrrolo[3,2-b]quinoxaline-3-carbonitrile | MLS000079890 | SMR000038250 | cid_657501
Type:
Small organic molecule
Emp. Form.:
C17H17N5
Mol. Mass.:
291.3504
SMILES:
Nc1c(C#N)c2nc3ccccc3nc2n1C1CCCCC1
Structure:
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