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Target
Orotidine 5'-phosphate decarboxylase
Ligand
BDBM83730
Substrate
n/a
Meas. Tech.
Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter
EC50
>59652±n/a nM
Citation
 PubChem, PC Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter PubChem Bioassay (2011)[AID] 
Target
Name:
Orotidine 5'-phosphate decarboxylase
Synonyms:
FXN frataxin | PYRF_ASPNG | pyrA | pyrG
Type:
Enzyme Catalytic Domain
Mol. Mass.:
30195.13
Organism:
Aspergillus niger
Description:
gi_2395
Residue:
277
Sequence:
MSSKSQLTYTARASKHPNALAKRLFEIAEAKKTNVTVSADVTTTKELLDLADRLGPYIAVIKTHIDILSDFSDETIEGLKALAQKHNFLIFEDRKFIDIGNTVQKQYHRGTLRISEWAHIINCSILPGEGIVEALAQTASAPDFSYGPERGLLILAEMTSKGSLATGQYTTSSVDYARKYKNFVMGFVSTRSLGEVQSEVSSPSDEEDFVVFTTGVNISSKGDKLGQQYQTPASAIGRGADFIIAGRGIYAAPDPVQAAQQYQKEGWEAYLARVGGN
  
Inhibitor
Name:
BDBM83730
Synonyms:
(2S,3S)-2-(1-adamantylcarbonyl)-5-azanyl-3-pyridin-4-yl-2,3-dihydrothiophene-4-carbonitrile | (2S,3S)-2-(adamantane-1-carbonyl)-5-amino-3-(4-pyridyl)-2,3-dihydrothiophene-4-carbonitrile | (2S,3S)-2-(adamantane-1-carbonyl)-5-amino-3-pyridin-4-yl-2,3-dihydrothiophene-4-carbonitrile | (2S,3S)-2-[1-adamantyl(oxo)methyl]-5-amino-3-pyridin-4-yl-2,3-dihydrothiophene-4-carbonitrile | MLS000038294 | SMR000041645 | cid_660930
Type:
Small organic molecule
Emp. Form.:
C21H23N3OS
Mol. Mass.:
365.492
SMILES:
[H]C12CC3([H])CC([H])(C1)CC(C2)(C3)C(=O)[C@H]1SC(=N)C(C#N)[C@@H]1c1ccncc1 |TLB:5:3:11:6.9.8,THB:2:3:9:1.11.8,5:6:11:3.12.2|
Structure:
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