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Target
Orotidine 5'-phosphate decarboxylase
Ligand
BDBM51519
Substrate
n/a
Meas. Tech.
Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter
EC50
>59644±n/a nM
Citation
 PubChem, PC Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter PubChem Bioassay (2011)[AID] 
Target
Name:
Orotidine 5'-phosphate decarboxylase
Synonyms:
FXN frataxin | PYRF_ASPNG | pyrA | pyrG
Type:
Enzyme Catalytic Domain
Mol. Mass.:
30195.13
Organism:
Aspergillus niger
Description:
gi_2395
Residue:
277
Sequence:
MSSKSQLTYTARASKHPNALAKRLFEIAEAKKTNVTVSADVTTTKELLDLADRLGPYIAVIKTHIDILSDFSDETIEGLKALAQKHNFLIFEDRKFIDIGNTVQKQYHRGTLRISEWAHIINCSILPGEGIVEALAQTASAPDFSYGPERGLLILAEMTSKGSLATGQYTTSSVDYARKYKNFVMGFVSTRSLGEVQSEVSSPSDEEDFVVFTTGVNISSKGDKLGQQYQTPASAIGRGADFIIAGRGIYAAPDPVQAAQQYQKEGWEAYLARVGGN
  
Inhibitor
Name:
BDBM51519
Synonyms:
9,10-dimethoxy-2-(3-pyridinylmethoxy)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one | 9,10-dimethoxy-2-(3-pyridylmethoxy)-6,7-dihydropyrimid[6,1-a]isoquinolin-4-one | 9,10-dimethoxy-2-(pyridin-3-ylmethoxy)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one | MLS000042488 | SMR000047302 | cid_666145
Type:
Small organic molecule
Emp. Form.:
C20H19N3O4
Mol. Mass.:
365.3826
SMILES:
COc1cc2CCn3c(cc(OCc4cccnc4)nc3=O)-c2cc1OC
Structure:
Search PDB for entries with ligand similarity: