Reaction Details Report a problem with these data
Target
Caspase-9
Ligand
BDBM33184
Substrate
n/a
Meas. Tech.
Dose response confirmation of uHTS hits for Apaf-1 using a LZ-Caspase-9/Caspase-3 Fluorescent Selectivity assay
IC50
12000±n/a nM
Citation
 PubChem, PC Dose response confirmation of uHTS hits for Apaf-1 using a LZ-Caspase-9/Caspase-3 Fluorescent Selectivity assay PubChem Bioassay (2011)[AID] 
Target
Name:
Caspase-9
Synonyms:
Apoptotic protease-activating factor 1/Caspase-3/Caspase-9/Cytochrome c | Apoptotic protease-activating factor 3 | CASP-9 | CASP9 | CASP9_HUMAN | Caspase 9 | ICE-like apoptotic protease 6 | MCH6 | caspase-9 isoform alpha preproprotein
Type:
Enzyme
Mol. Mass.:
46277.29
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
416
Sequence:
MDEADRRLLRRCRLRLVEELQVDQLWDALLSRELFRPHMIEDIQRAGSGSRRDQARQLIIDLETRGSQALPLFISCLEDTGQDMLASFLRTNRQAAKLSKPTLENLTPVVLRPEIRKPEVLRPETPRPVDIGSGGFGDVGALESLRGNADLAYILSMEPCGHCLIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQDHGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGIYKQMPGCFNFLRKKLFFKTS
  
Inhibitor
Name:
BDBM33184
Synonyms:
2-[1-oxidanylidene-4-(2,4,5-trimethylphenyl)sulfonylimino-naphthalen-2-yl]sulfanylethanoic acid | 2-[1-oxo-4-(2,4,5-trimethylphenyl)sulfonyliminonaphthalen-2-yl]sulfanylacetic acid | 2-[[1-keto-4-(2,4,5-trimethylphenyl)sulfonylimino-2-naphthyl]thio]acetic acid | 2-[[1-oxo-4-(2,4,5-trimethylphenyl)sulfonylimino-2-naphthalenyl]thio]acetic acid | MLS000689768 | SMR000313372 | [((4Z)-1-oxo-4-{[(2,4,5-trimethylphenyl)sulfonyl]imino}-1,4-dihydronaphthalen-2-yl)thio]acetic acid | cid_3676835
Type:
Small organic molecule
Emp. Form.:
C21H19NO5S2
Mol. Mass.:
429.509
SMILES:
Cc1cc(C)c(cc1C)S(=O)(=O)N=C1C=C(SCC(O)=O)C(=O)c2ccccc12 |w:12.12,t:15|
Structure:
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