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Target
Multidrug efflux pump
Ligand
BDBM84147
Substrate
n/a
Meas. Tech.
Dose Response HTS singleplex for inhibitors of yeast efflux pump, specifically Mdr1 with Hit compounds from Cherry Pick1
EC50
3990±n/a nM
Citation
 PubChem, PC Dose Response HTS singleplex for inhibitors of yeast efflux pump, specifically Mdr1 with Hit compounds from Cherry Pick1 PubChem Bioassay (2011)[AID] 
Target
Name:
Multidrug efflux pump
Synonyms:
Candida albicans strain ATCC 10261 multidrug efflux pump (MDR1) gene, MDR1-A allele, complete cds
Type:
Enzyme Catalytic Domain
Mol. Mass.:
62915.82
Organism:
Candida albicans
Description:
Q09GR2
Residue:
564
Sequence:
MHYRFLRDSFVGRVTYHLSKHKYFAHPEEAKDYIVPEKYLADYKPTLADDTSINFEKEEIDNQGEPNSSQSSSSNNTIVDNNNNNDNDVDGDKIVVTWDGDDDPENPQNWPTLQKAFFIFQISFLTTSVYMGSAVYTPGIEELMHDFGIGRVVATLPLTLFVIGYGVGPLVFSPMSENAIFGRTSIYIITLFLFVILQIPTALVNNIAGLCILRFLGGFFASPCLATGGASVADVVKFWNLPVGLAAWSLGAVCGPSFGPFFGSILTVKASWRWTFWFMCIISGFSFVMLCFTLPETFGKTLLYRKAKRLRAITGNDRITSEGEIENSKMTSHELIIDTLWRPLEITVMEPVVLLINIYIAMVYSILYLFFEVFPIYFVGVKHFTLVELGTTYMSIVIGIVIAAFIYIPVIRQKFTKPILRQEQVFPEVFIPIAIVGGILLTSGLFIFGWSANRTTHWVGPLFGAATTASGAFLIFQTLFNFMGASFKPHYIASVFASNDLFRSVIASVFPLFGAPLFDNLATPEYPVAWGSSVLGFITLVMIAIPVLFYLNGPKLRARSKYAN
  
Inhibitor
Name:
BDBM84147
Synonyms:
2,6-Dichloro-4-(1,2-dihydro-3,9,9a-triaza-fluoren-4-yl)-phenylamine | 2,6-bis(chloranyl)-4-(3,4-dihydropyrazino[1,2-b]indazol-1-yl)aniline | 2,6-dichloro-4-(3,4-dihydropyrazino[1,2-b]indazol-1-yl)aniline | MLS001101506 | SMR001216730 | [2,6-dichloro-4-(3,4-dihydropyrazin[1,2-b]indazol-1-yl)phenyl]amine | cid_24979614
Type:
Small organic molecule
Emp. Form.:
C16H12Cl2N4
Mol. Mass.:
331.199
SMILES:
Nc1c(Cl)cc(cc1Cl)C1=NCCn2nc3ccccc3c12 |t:10|
Structure:
Search PDB for entries with ligand similarity: