Reaction Details Report a problem with these data
Target
Zinc finger and BTB domain-containing protein 16
Ligand
BDBM50239368
Substrate
n/a
Meas. Tech.
ChEMBL_1665992 (CHEMBL4015788)
IC50
>30000±n/a nM
Citation
 McCoull, W; Abrams, RD; Anderson, E; Blades, K; Barton, P; Box, M; Burgess, J; Byth, K; Cao, Q; Chuaqui, C; Carbajo, RJ; Cheung, T; Code, E; Ferguson, AD; Fillery, S; Fuller, NO; Gangl, E; Gao, N; Grist, M; Hargreaves, D; Howard, MR; Hu, J; Kemmitt, PD; Nelson, JE; O'Connell, N; Prince, DB; Raubo, P; Rawlins, PB; Robb, GR; Shi, J; Waring, MJ; Whittaker, D; Wylot, M; Zhu, X Discovery of Pyrazolo[1,5-a]pyrimidine B-Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors. J Med Chem 60:4386-4402 (2017) [PubMed]  Article 
Target
Name:
Zinc finger and BTB domain-containing protein 16
Synonyms:
PLZF | Promyelocytic leukemia zinc finger protein | ZBT16_HUMAN | ZBTB16 | ZNF145 | Zinc finger and BTB domain-containing protein 16 | Zinc finger protein 145 | Zinc finger protein PLZF
Type:
PROTEIN
Mol. Mass.:
74272.31
Organism:
Homo sapiens
Description:
ChEMBL_117331
Residue:
673
Sequence:
MDLTKMGMIQLQNPSHPTGLLCKANQMRLAGTLCDVVIMVDSQEFHAHRTVLACTSKMFEILFHRNSQHYTLDFLSPKTFQQILEYAYTATLQAKAEDLDDLLYAAEILEIEYLEEQCLKMLETIQASDDNDTEATMADGGAEEEEDRKARYLKNIFISKHSSEESGYASVAGQSLPGPMVDQSPSVSTSFGLSAMSPTKAAVDSLMTIGQSLLQGTLQPPAGPEEPTLAGGGRHPGVAEVKTEMMQVDEVPSQDSPGAAESSISGGMGDKVEERGKEGPGTPTRSSVITSARELHYGREESAEQVPPPAEAGQAPTGRPEHPAPPPEKHLGIYSVLPNHKADAVLSMPSSVTSGLHVQPALAVSMDFSTYGGLLPQGFIQRELFSKLGELAVGMKSESRTIGEQCSVCGVELPDNEAVEQHRKLHSGMKTYGCELCGKRFLDSLRLRMHLLAHSAGAKAFVCDQCGAQFSKEDALETHRQTHTGTDMAVFCLLCGKRFQAQSALQQHMEVHAGVRSYICSECNRTFPSHTALKRHLRSHTGDHPYECEFCGSCFRDESTLKSHKRIHTGEKPYECNGCGKKFSLKHQLETHYRVHTGEKPFECKLCHQRSRDYSAMIKHLRTHNGASPYQCTICTEYCPSLSSMQKHMKGHKPEEIPPDWRIEKTYLYLCYV
  
Inhibitor
Name:
BDBM50239368
Synonyms:
CHEMBL4073463
Type:
Small organic molecule
Emp. Form.:
C33H33N7O5
Mol. Mass.:
607.659
SMILES:
[H][C@]12C[C@@H](CO)N(C1)c1cc(Nc3cc4CCC(=O)N(Cc5cccc(OC)c5)c4c(OC\C=C\CO2)c3)n2ncc(C#N)c2n1 |r,t:36|
Structure:
Search PDB for entries with ligand similarity: