Reaction Details Report a problem with these data
Target
Glucose-dependent insulinotropic receptor
Ligand
BDBM50240387
Substrate
n/a
Meas. Tech.
ChEMBL_1668157 (CHEMBL4018045)
EC50
1.2±n/a nM
Citation
 Yang, Z; Fang, Y; Park, H Synthesis and biological evaluation of pyrimidine derivatives with diverse azabicyclic ether/amine as novel GPR119 agonist. Bioorg Med Chem Lett 27:2515-2519 (2017) [PubMed]  Article 
Target
Name:
Glucose-dependent insulinotropic receptor
Synonyms:
G-protein coupled receptor 119 (GPR119) | GP119_HUMAN | GPR119 | Glucose-dependent insulinotropic receptor
Type:
Protein
Mol. Mass.:
36901.49
Organism:
Homo sapiens (Human)
Description:
Q8TDV5
Residue:
335
Sequence:
MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
  
Inhibitor
Name:
BDBM50240387
Synonyms:
CHEMBL4098760
Type:
Small organic molecule
Emp. Form.:
C23H28FN5O7S
Mol. Mass.:
537.561
SMILES:
[H][C@@]12CC[C@]([H])(C[C@@H]1Oc1ncnc(Nc3ccc(cc3F)S(C)(=O)=O)c1[N+]([O-])=O)N(C2)C(=O)OC(C)(C)C |r,TLB:8:7:3.2:31.30,THB:32:30:7.6:3.2|
Structure:
Search PDB for entries with ligand similarity: