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Target
Carbonic anhydrase 2
Ligand
BDBM50240926
Substrate
n/a
Meas. Tech.
ChEMBL_1669310 (CHEMBL4019198)
Kd
>2000000±n/a nM
Citation
 Chrysanthopoulos, PK; Mujumdar, P; Woods, LA; Dolezal, O; Ren, B; Peat, TS; Poulsen, SA Identification of a New Zinc Binding Chemotype by Fragment Screening. J Med Chem 60:7333-7349 (2017) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Homo sapiens (Human)
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM50240926
Synonyms:
CHEMBL4077844
Type:
Small organic molecule
Emp. Form.:
C12H14N2O4
Mol. Mass.:
250.2506
SMILES:
COc1ccc(CC2NC(=O)NC2=O)c(OC)c1
Structure:
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