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Target
Survival motor neuron protein
Ligand
BDBM50242602
Substrate
n/a
Meas. Tech.
ChEMBL_1671880 (CHEMBL4021909)
EC50
1500±n/a nM
Citation
Rietz, A; Li, H; Quist, KM; Cherry, JJ; Lorson, CL; Burnett, BG; Kern, NL; Calder, AN; Fritsche, M; Lusic, H; Boaler, PJ; Choi, S; Xing, X; Glicksman, MA; Cuny, GD; Androphy, EJ; Hodgetts, KJ Discovery of a Small Molecule Probe That Post-Translationally Stabilizes the Survival Motor Neuron Protein for the Treatment of Spinal Muscular Atrophy. J Med Chem 60:4594-4610 (2017) [PubMed] Article
More Info.:
Target
Name:
Survival motor neuron protein
Synonyms:
Component of gems 1 | Gemin-1 | SMN | SMN1 | SMN2 | SMNC | SMNT | SMN_HUMAN | Survival motor neuron protein
Type:
PROTEIN
Mol. Mass.:
31848.37
Organism:
Homo sapiens
Description:
ChEMBL_103665
Residue:
294
Sequence:
MAMSSGGSGGGVPEQEDSVLFRRGTGQSDDSDIWDDTALIKAYDKAVASFKHALKNGDICETSGKPKTTPKRKPAKKNKSQKKNTAASLQQWKVGDKCSAIWSEDGCIYPATIASIDFKRETCVVVYTGYGNREEQNLSDLLSPICEVANNIEQNAQENENESQVSTDESENSRSPGNKSDNIKPKSAPWNSFLPPPPPMPGPRLGPGKPGLKFNGPPPPPPPPPPHLLSCWLPPFPSGPPIIPPPPPICPDSLDDADALGSMLISWYMSGYHTGYYMGFRQNQKEGRCSHSLN