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Target
Peroxisome proliferator-activated receptor delta
Ligand
BDBM50244348
Substrate
n/a
Meas. Tech.
ChEMBL_1673574 (CHEMBL4023603)
EC50
697±n/a nM
Citation
 Boubia, B; Poupardin, O; Barth, M; Binet, J; Peralba, P; Mounier, L; Jacquier, E; Gauthier, E; Lepais, V; Chatar, M; Ferry, S; Thourigny, A; Guillier, F; Llacer, J; Amaudrut, J; Dodey, P; Lacombe, O; Masson, P; Montalbetti, C; Wettstein, G; Luccarini, JM; Legendre, C; Junien, JL; Broqua, P Design, Synthesis, and Evaluation of a Novel Series of Indole Sulfonamide Peroxisome Proliferator Activated Receptor (PPAR)?/?/? Triple Activators: Discovery of Lanifibranor, a New Antifibrotic Clinical Candidate. J Med Chem 61:2246-2265 (2018) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor delta
Synonyms:
NR1C2 | NUC1 | NUCI | Nuclear hormone receptor 1 | Nuclear receptor subfamily 1 group C member 2 | PPAR delta | PPAR-beta | PPARB | PPARD | PPARD_HUMAN | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor beta | Peroxisome proliferator-activated receptor delta
Type:
Enzyme
Mol. Mass.:
49910.45
Organism:
Homo sapiens (Human)
Description:
Q03181
Residue:
441
Sequence:
MEQPQEEAPEVREEEEKEEVAEAEGAPELNGGPQHALPSSSYTDLSRSSSPPSLLDQLQMGCDGASCGSLNMECRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYEKCERSCKIQKKNRNKCQYCRFQKCLALGMSHNAIRFGRMPEAEKRKLVAGLTANEGSQYNPQVADLKAFSKHIYNAYLKNFNMTKKKARSILTGKASHTAPFVIHDIETLWQAEKGLVWKQLVNGLPPYKEISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQVTLLKYGVHEAIFAMLASIVNKDGLLVANGSGFVTREFLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLALFIAAIILCGDRPGLMNVPRVEAIQDTILRALEFHLQANHPDAQYLFPKLLQKMADLRQLVTEHAQMMQRIKKTETETSLHPLLQEIYKDMY
  
Inhibitor
Name:
BDBM50244348
Synonyms:
CHEMBL4083589
Type:
Small organic molecule
Emp. Form.:
C21H21ClN2O5S
Mol. Mass.:
448.92
SMILES:
CN1CCOc2ccc(cc12)S(=O)(=O)n1c(CCCC(O)=O)cc2cc(Cl)ccc12
Structure:
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