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Target
Peroxisome proliferator-activated receptor gamma
Ligand
BDBM50244325
Substrate
n/a
Meas. Tech.
ChEMBL_1673576 (CHEMBL4023605)
EC50
256±n/a nM
Citation
 Boubia, B; Poupardin, O; Barth, M; Binet, J; Peralba, P; Mounier, L; Jacquier, E; Gauthier, E; Lepais, V; Chatar, M; Ferry, S; Thourigny, A; Guillier, F; Llacer, J; Amaudrut, J; Dodey, P; Lacombe, O; Masson, P; Montalbetti, C; Wettstein, G; Luccarini, JM; Legendre, C; Junien, JL; Broqua, P Design, Synthesis, and Evaluation of a Novel Series of Indole Sulfonamide Peroxisome Proliferator Activated Receptor (PPAR)?/?/? Triple Activators: Discovery of Lanifibranor, a New Antifibrotic Clinical Candidate. J Med Chem 61:2246-2265 (2018) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor gamma
Synonyms:
NR1C3 | Nuclear receptor subfamily 1 group C member 3 | PPAR-gamma | PPARG | PPARG_HUMAN | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor gamma (PPAR gamma) | Peroxisome proliferator-activated receptor gamma (PPARG) | Peroxisome proliferator-activated receptor gamma (PPARĪ³) | Peroxisome proliferator-activated receptor gamma/Nuclear receptor corepressor 2 | peroxisome proliferator-activated receptor gamma isoform 2
Type:
Nuclear Receptor
Mol. Mass.:
57613.46
Organism:
Homo sapiens (Human)
Description:
P37231
Residue:
505
Sequence:
MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY
  
Inhibitor
Name:
BDBM50244325
Synonyms:
CHEMBL4067479
Type:
Small organic molecule
Emp. Form.:
C19H15ClF3NO4S
Mol. Mass.:
445.84
SMILES:
OC(=O)CCCc1cc2cc(ccc2n1S(=O)(=O)c1cccc(Cl)c1)C(F)(F)F
Structure:
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