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Target
Protein arginine N-methyltransferase 7
Ligand
BDBM50247634
Substrate
n/a
Meas. Tech.
ChEMBL_1678258 (CHEMBL4028401)
IC50
20000±n/a nM
Citation
 Babault, N; Allali-Hassani, A; Li, F; Fan, J; Yue, A; Ju, K; Liu, F; Vedadi, M; Liu, J; Jin, J Discovery of Bisubstrate Inhibitors of Nicotinamide N-Methyltransferase (NNMT). J Med Chem 61:1541-1551 (2018) [PubMed]  Article 
Target
Name:
Protein arginine N-methyltransferase 7
Synonyms:
ANM7_HUMAN | Histone-arginine N-methyltransferase PRMT7 | KIAA1933 | PRMT7 | Protein arginine N-methyltransferase 7 | Protein arginine methyltransferase 7 (PRMT7) | [Myelin basic protein]-arginine N-methyltransferase PRMT7
Type:
Enzyme
Mol. Mass.:
78440.77
Organism:
Homo sapiens (Human)
Description:
Q9NVM4
Residue:
692
Sequence:
MKIFCSRANPTTGSVEWLEEDEHYDYHQEIARSSYADMLHDKDRNVKYYQGIRAAVSRVKDRGQKALVLDIGTGTGLLSMMAVTAGADFCYAIEVFKPMADAAVKIVEKNGFSDKIKVINKHSTEVTVGPEGDMPCRANILVTELFDTELIGEGALPSYEHAHRHLVEENCEAVPHRATVYAQLVESGRMWSWNKLFPIHVQTSLGEQVIVPPVDVESCPGAPSVCDIQLNQVSPADFTVLSDVLPMFSIDFSKQVSSSAACHSRRFEPLTSGRAQVVLSWWDIEMDPEGKIKCTMAPFWAHSDPEEMQWRDHWMQCVYFLPQEEPVVQGSALYLVAHHDDYCVWYSLQRTSPEKNERVRQMRPVCDCQAHLLWNRPRFGEINDQDRTDRYVQALRTVLKPDSVCLCVSDGSLLSVLAHHLGVEQVFTVESSAASHKLLRKIFKANHLEDKINIIEKRPELLTNEDLQGRKVSLLLGEPFFTTSLLPWHNLYFWYVRTAVDQHLGPGAMVMPQAASLHAVVVEFRDLWRIRSPCGDCEGFDVHIMDDMIKRALDFRESREAEPHPLWEYPCRSLSEPWQILTFDFQQPVPLQPLCAEGTVELRRPGQSHAAVLWMEYHLTPECTLSTGLLEPADPEGGCCWNPHCKQAVYFFSPAPDPRALLGGPRTVSYAVEFHPDTGDIIMEFRHADTPD
  
Inhibitor
Name:
BDBM50247634
Synonyms:
CHEMBL4067973
Type:
Small organic molecule
Emp. Form.:
C24H32N8O6
Mol. Mass.:
528.5609
SMILES:
N[C@@H](CCCN(CCc1cccc(c1)C(N)=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O |r|
Structure:
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