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Target
Inward rectifier potassium channel 2
Ligand
BDBM50249183
Substrate
n/a
Meas. Tech.
ChEMBL_1679758 (CHEMBL4030035)
IC50
>100000±n/a nM
Citation
Dong, S; VanGelder, K; Shi, ZC; Yu, Y; Wu, Z; Ferguson, R; Guo, ZZ; Tang, H; Frie, J; Fu, Q; Gu, X; Priest, BT; Thomas-Fowlkes, B; Weinglass, A; Margulis, M; Liu, J; Pai, LY; Hampton, C; Haimbach, RE; Owens, K; Tong, V; Xu, S; Hu, M; Zingaro, GJ; Morissette, P; Ehrhart, J; Roy, S; Sullivan, K; Pasternak, A Improvement of hERG-ROMK index of spirocyclic ROMK inhibitors through scaffold optimization and incorporation of novel pharmacophores. Bioorg Med Chem Lett 27:2559-2566 (2017) [PubMed] Article
More Info.:
Target
Name:
Inward rectifier potassium channel 2
Synonyms:
Cardiac inward rectifier potassium channel | IRK-1 | IRK1 | Inward rectifier K(+) channel Kir2.1 | KCNJ2 | KCNJ2_HUMAN | Potassium channel, inwardly rectifying subfamily J member 2 | hIRK1
Type:
PROTEIN
Mol. Mass.:
48281.20
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1515520
Residue:
427
Sequence:
MGSVRTNRYSIVSSEEDGMKLATMAVANGFGNGKSKVHTRQQCRSRFVKKDGHCNVQFINVGEKGQRYLADIFTTCVDIRWRWMLVIFCLAFVLSWLFFGCVFWLIALLHGDLDASKEGKACVSEVNSFTAAFLFSIETQTTIGYGFRCVTDECPIAVFMVVFQSIVGCIIDAFIIGAVMAKMAKPKKRNETLVFSHNAVIAMRDGKLCLMWRVGNLRKSHLVEAHVRAQLLKSRITSEGEYIPLDQIDINVGFDSGIDRIFLVSPITIVHEIDEDSPLYDLSKQDIDNADFEIVVILEGMVEATAMTTQCRSSYLANEILWGHRYEPVLFEEKHYYKVDYSRFHKTYEVPNTPLCSARDLAEKKYILSNANSFCYENEVALTSKEEDDSENGVPESTSTDTPPDIDLHNQASVPLEPRPLRRESEI