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Target
S-adenosylmethionine decarboxylase proenzyme
Ligand
BDBM50254826
Substrate
n/a
Meas. Tech.
ChEBML_1686749
IC50
44000±n/a nM
Citation
 Volkov, OA; Brockway, AJ; Wring, SA; Peel, M; Chen, Z; Phillips, MA; De Brabander, JK Species-Selective Pyrimidineamine Inhibitors of Trypanosoma brucei S-Adenosylmethionine Decarboxylase. J Med Chem 61:1182-1203 (2018) [PubMed]  Article 
Target
Name:
S-adenosylmethionine decarboxylase proenzyme
Synonyms:
AMD | AMD1 | DCAM_HUMAN | S-Adenosylmethionine Decarboxylase (AdoMetDC) | S-adenosylmethionine decarboxylase 1 | SAMDC
Type:
Heterotetramer of two alpha and two beta chains
Mol. Mass.:
38337.21
Organism:
Homo sapiens (Human)
Description:
For the production of protein for the hAdoMetDC enzyme assays, the plasmid containing (H)6 tag at the carboxyl end (replacing -QQQQQS) was used.
Residue:
334
Sequence:
MEAAHFFEGTEKLLEVWFSRQQPDANQGSGDLRTIPRSEWDILLKDVQCSIISVTKTDKQEAYVLSESSMFVSKRRFILKTCGTTLLLKALVPLLKLARDYSGFDSIQSFFYSRKNFMKPSHQGYPHRNFQEEIEFLNAIFPNGAAYCMGRMNSDCWYLYTLDFPESRVISQPDQTLEILMSELDPAVMDQFYMKDGVTAKDVTRESGIRDLIPGSVIDATMFNPCGYSMNGMKSDGTYWTIHITPEPEFSYVSFETNLSQTSYDDLIRKVVEVFKPGKFVTTLFVNQSSKCRTVLASPQKIEGFKRLDCQSAMFNDYNFVFTSFAKKQQQQQS
  
Inhibitor
Name:
BDBM50254826
Synonyms:
CHEMBL4090615
Type:
Small organic molecule
Emp. Form.:
C13H12BrF3N4O
Mol. Mass.:
377.16
SMILES:
Cc1cc(Nc2cc(Br)cc(OCC(F)(F)F)c2)nc(N)n1
Structure:
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