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Target
Mu-type opioid receptor
Ligand
BDBM50256743
Substrate
n/a
Meas. Tech.
ChEBML_1688176
Ki
1.2±n/a nM
Citation
 Adamska-Bart?omiejczyk, A; De Marco, R; Gentilucci, L; Kluczyk, A; Janecka, A Design and characterization of opioid ligands based on cycle-in-macrocycle scaffold. Bioorg Med Chem 25:2399-2405 (2017) [PubMed]  Article 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM50256743
Synonyms:
CHEMBL4085033
Type:
Small organic molecule
Emp. Form.:
C34H45N7O7
Mol. Mass.:
663.7638
SMILES:
N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H]1CCCCNC(=O)C[C@H](NC(=O)C2CCN(CC2)C(=O)[C@H](Cc2ccccc2)NC1=O)C(N)=O |r,wU:1.1,34.36,13.13,wD:22.48,(31.33,-29.37,;31.36,-27.84,;30.06,-27.03,;28.71,-27.77,;28.67,-29.31,;27.33,-30.05,;26,-29.25,;24.66,-29.99,;26.04,-27.71,;27.38,-26.97,;32.71,-27.09,;32.75,-25.56,;34.11,-27.94,;35.54,-27.15,;36.86,-27.94,;38.21,-27.22,;39.51,-28.01,;40.86,-27.27,;40.9,-25.73,;42.25,-24.98,;43.52,-25.82,;42.25,-20.87,;43.65,-20.12,;43.7,-18.53,;41.31,-17.46,;41.22,-15.87,;39.93,-18.27,;40.72,-19.65,;39.93,-21.02,;38.34,-21.02,;37.54,-19.65,;38.34,-18.27,;38.3,-22.61,;39.66,-23.44,;36.96,-23.34,;35.61,-22.6,;34.89,-21.23,;35.71,-19.94,;35,-18.57,;33.46,-18.52,;32.64,-19.83,;33.36,-21.18,;36.93,-24.88,;35.57,-25.61,;34.26,-24.82,;45.01,-20.96,;46.41,-20.21,;44.96,-22.55,)|
Structure:
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