Reaction Details Report a problem with these data
Target
Kappa-type opioid receptor
Ligand
BDBM50257767
Substrate
n/a
Meas. Tech.
ChEBML_1689990
IC50
800±n/a nM
Citation
 Ravilla, L; Venkata Subba Naidu, N; Dogra, S; Umrao, D; Yadav, PN; Biswas, A; Michael, D; Sekar, K; Nagarajan, K Opioid Receptor Modulators with a Cinnamyl Group. J Med Chem 60:6733-6750 (2017) [PubMed]  Article 
Target
Name:
Kappa-type opioid receptor
Synonyms:
K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42648.76
Organism:
Homo sapiens (Human)
Description:
P41145
Residue:
380
Sequence:
MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV
  
Inhibitor
Name:
BDBM50257767
Synonyms:
CHEMBL4097541
Type:
Small organic molecule
Emp. Form.:
C20H20Cl2N2O2
Mol. Mass.:
391.291
SMILES:
OC(=O)C(\CN1CCN(CC1)c1cccc(Cl)c1Cl)=C\c1ccccc1
Structure:
Search PDB for entries with ligand similarity: