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Target
Kappa-type opioid receptor
Ligand
BDBM50257766
Substrate
n/a
Meas. Tech.
ChEBML_1689990
IC50
1800±n/a nM
Citation
 Ravilla, L; Venkata Subba Naidu, N; Dogra, S; Umrao, D; Yadav, PN; Biswas, A; Michael, D; Sekar, K; Nagarajan, K Opioid Receptor Modulators with a Cinnamyl Group. J Med Chem 60:6733-6750 (2017) [PubMed]  Article 
Target
Name:
Kappa-type opioid receptor
Synonyms:
K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42648.76
Organism:
Homo sapiens (Human)
Description:
P41145
Residue:
380
Sequence:
MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV
  
Inhibitor
Name:
BDBM50257766
Synonyms:
CHEMBL4105243
Type:
Small organic molecule
Emp. Form.:
C26H32ClN3O3
Mol. Mass.:
470.004
SMILES:
CC(C)CC(NC(=O)C(\CN1CCN(CC1)c1cccc(Cl)c1)=C\c1ccccc1)C(O)=O
Structure:
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